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Premature Adrenarche

Premature Adrenarche is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

Appearance of pubic hair younger than age 8 years in girls and age 9 years in boys
Recent data suggest that the age of normal sexual development onset in girls is younger than previously recognized, but lowering of the traditionally accepted limits remains subject to debate.
Axillary hair, acne, and apocrine sweat gland secretion are not always present with premature adrenarche.
No other signs of sexual development are exhibited. Presence of breast development in girls or testicular enlargement in boys suggests precocious puberty and not premature adrenarche.
Occurs independently of hypothalamic–pituitary–gonadal axis activation

Genetics

Often sporadic. Familial patterns suggesting recessive and dominant inheritance have been described.

Pathophysiology

Concentrations of adrenal steroids such as dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) increase earlier than typically seen in normal puberty.
Adrenal zona reticularis normally begins to increase androgen secretion at age 7–8 years.

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Citation

Cabana, Michael D., editor. "Premature Adrenarche." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14185/all/Premature_Adrenarche.

Premature Adrenarche. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14185/all/Premature_Adrenarche. Accessed February 19, 2019.

Premature Adrenarche. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14185/all/Premature_Adrenarche

Premature Adrenarche [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 February 19]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14185/all/Premature_Adrenarche

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TY - ELEC T1 - Premature Adrenarche ID - 14185 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14185/all/Premature_Adrenarche PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -