Transient Erythroblastopenia of Childhood
Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:
-- The first section of this topic is shown below --
An acquired, self-limited suppression of red cell production in an otherwise healthy child
- Mean age at diagnosis is 26 months.
- <10% are >3 years of age at diagnosis.
- Slight male predominance (male/female 5.1:3.1)
- No seasonal predominance
- There is no simple genetic pattern.
- Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.
There is no known way to prevent transient erythroblastopenia of childhood.
- Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
- A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.