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    Eosinophilic Esophagitis

    Eosinophilic Esophagitis is a topic covered in the Select 5-Minute Pediatrics Topics.

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    Basics

    Description

    • Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease characterized clinically by variable symptoms of esophageal dysfunction and pathologically by localized eosinophilic inflammation.
    • The diagnosis is established in symptomatic patients who have the following:
      • At least 15 eosinophils/HPF isolated to the esophagus on endoscopic biopsies
      • Persistent eosinophilic infiltrate in esophageal biopsies after a trial of proton pump inhibitor (PPI) therapy

    Epidemiology

    • Incidence rates range from 0.7 to 10 per 100,000 person-years, and prevalence from 0.2 to 43 per 100,000.
    • 3:1 male-to-female ratio
    • Peaks of onset in childhood and 3rd–4th decade

    Pathophysiology

    • The exact pathophysiology of EoE is unknown but likely involves an immune response to environmental antigens in genetically predisposed individuals.
    • Environmental factors (food and possibly aeroallergens) trigger inflammatory response mediated by type 2 T-helper (Th2) cells.
    • Genetic polymorphisms which predispose to EoE include eotaxin-3, thymic stromal lymphopoietin, and filaggrin.

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    Citation

    Cabana, Michael D., editor. "Eosinophilic Esophagitis." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis.
    Eosinophilic Esophagitis. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis. Accessed April 21, 2019.
    Eosinophilic Esophagitis. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis
    Eosinophilic Esophagitis [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 April 21]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Eosinophilic Esophagitis ID - 14169 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -