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Eosinophilic Esophagitis

Eosinophilic Esophagitis is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease characterized clinically by variable symptoms of esophageal dysfunction and pathologically by localized eosinophilic inflammation.
The diagnosis is established in symptomatic patients who have the following:
- At least 15 eosinophils/HPF isolated to the esophagus on endoscopic biopsies
- Persistent eosinophilic infiltrate in esophageal biopsies after a trial of proton pump inhibitor (PPI) therapy

Epidemiology

Incidence rates range from 0.7 to 10 per 100,000 person-years, and prevalence from 0.2 to 43 per 100,000.
3:1 male-to-female ratio
Peaks of onset in childhood and 3rd–4th decade

Pathophysiology

The exact pathophysiology of EoE is unknown but likely involves an immune response to environmental antigens in genetically predisposed individuals.
Environmental factors (food and possibly aeroallergens) trigger inflammatory response mediated by type 2 T-helper (Th2) cells.
Genetic polymorphisms which predispose to EoE include eotaxin-3, thymic stromal lymphopoietin, and filaggrin.

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Citation

Cabana, Michael D., editor. "Eosinophilic Esophagitis." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis.

Eosinophilic Esophagitis. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis. Accessed February 22, 2019.

Eosinophilic Esophagitis. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis

Eosinophilic Esophagitis [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 February 22]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis

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TY - ELEC T1 - Eosinophilic Esophagitis ID - 14169 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14169/all/Eosinophilic_Esophagitis PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -