Type your tag names separated by a space and hit enter

Floppy Infant Syndrome

Floppy Infant Syndrome is a topic covered in the Select 5-Minute Pediatrics Topics.

To view the entire topic, please or purchase a subscription.

Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:

Medicine Central

-- The first section of this topic is shown below --



  • “Floppy infant” refers to the newborn/infant presenting at birth or early in life with hypotonia, a symptom of diminished tone of skeletal muscles associated with decreased resistance of muscles to passive stretching.
  • Hypotonia can be caused by abnormalities of the CNS (central hypotonia), peripheral neuromuscular system (peripheral hypotonia), or combined abnormality involving both (combined hypotonia).
  • Nonspecific transient hypotonia occurs in nonneurologic conditions and may suggest gastrointestinal (GI), cardiac, pulmonary, infectious, renal, or endocrine disease.


No comprehensive prevalence known owing to presence of hypotonia as a feature of many distinct disorders; overall, central hypotonia is more common than peripheral hypotonia.

Risk Factors


Substantial proportion (>50%) of infantile hypotonia cases accounted for by genetic-metabolic disorders.


Causes may be divided into two major categories:

  • Central: hypotonia with decreased alertness, developmental delay, and lack of or minimal weakness; caused by upper motor neuron defect
  • Peripheral: hypotonia with profound weakness, paucity of antigravity movements, decreased or absent deep tendon reflexes (DTRs), and visual alertness; caused by lower motor neuron defect (i.e., disorders of anterior horn cell, peripheral nerve, neuromuscular junction, or skeletal muscle)

Commonly Associated Conditions

  • Respiratory problems (apnea/hypoventilation)
  • Feeding/swallowing difficulties
  • Hip dislocation/contractures/joint laxity
  • Seizure disorder
  • Cognitive/developmental delay
  • Hypersomnolence

-- To view the remaining sections of this topic, please or purchase a subscription --


Cabana, Michael D., editor. "Floppy Infant Syndrome." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14164/all/Floppy_Infant_Syndrome.
Floppy Infant Syndrome. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14164/all/Floppy_Infant_Syndrome. Accessed April 25, 2019.
Floppy Infant Syndrome. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14164/all/Floppy_Infant_Syndrome
Floppy Infant Syndrome [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 April 25]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14164/all/Floppy_Infant_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Floppy Infant Syndrome ID - 14164 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14164/all/Floppy_Infant_Syndrome PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -