Floppy Infant Syndrome
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- “Floppy infant” refers to the newborn/infant presenting at birth or early in life with hypotonia, a symptom of diminished tone of skeletal muscles associated with decreased resistance of muscles to passive stretching.
- Hypotonia can be caused by abnormalities of the CNS (central hypotonia), peripheral neuromuscular system (peripheral hypotonia), or combined abnormality involving both (combined hypotonia).
- Nonspecific transient hypotonia occurs in nonneurologic conditions and may suggest gastrointestinal (GI), cardiac, pulmonary, infectious, renal, or endocrine disease.
No comprehensive prevalence known owing to presence of hypotonia as a feature of many distinct disorders; overall, central hypotonia is more common than peripheral hypotonia.
Substantial proportion (>50%) of infantile hypotonia cases accounted for by genetic-metabolic disorders.
Causes may be divided into two major categories:
- Central: hypotonia with decreased alertness, developmental delay, and lack of or minimal weakness; caused by upper motor neuron defect
- Peripheral: hypotonia with profound weakness, paucity of antigravity movements, decreased or absent deep tendon reflexes (DTRs), and visual alertness; caused by lower motor neuron defect (i.e., disorders of anterior horn cell, peripheral nerve, neuromuscular junction, or skeletal muscle)
Commonly Associated Conditions
- Respiratory problems (apnea/hypoventilation)
- Feeding/swallowing difficulties
- Hip dislocation/contractures/joint laxity
- Seizure disorder
- Cognitive/developmental delay