Bone Marrow and Stem Cell Transplant

Bone Marrow and Stem Cell Transplant is a topic covered in the Select 5-Minute Pediatrics Topics.

To view the entire topic, please or purchase a subscription.

Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:

Medicine Central

-- The first section of this topic is shown below --

Basics

Description

  • Hematopoietic stem cell transplantation (HSCT) is the infusion of progenitor stem cells with the intention of restoring hematopoiesis and immunity. HSCT can be classified by
    • Donor type: syngeneic (derived from an identical twin), allogeneic (derived from a related or unrelated donor), or autologous (derived from the patient prior to stem cell-toxic therapy)
    • Product type
      • Bone marrow transplantation (BMT): Stem cells are obtained by harvesting bone marrow under anesthesia.
      • Peripheral blood stem cell transplantation (PBSCT): Stem cells are mobilized to the periphery with cytokines (GCSF) and collected by apheresis.
      • Umbilical cord blood transplantation (UCBT): Stem cells are collected from the umbilical cord and placenta following delivery.
  • Stem cells are infused in the peripheral blood of the recipient using a central venous catheter, similar to a blood transfusion. They then home to the bone marrow niche and over the next 2–4 weeks differentiate into mature blood components.

Epidemiology

  • In 2010, 1,479 pediatric allogeneic (and 782 autologous) HSCTs were performed in the United States. Approximately 40% of allogeneic transplants are from matched related donors.
  • The use of unrelated PBSCT and unrelated UCBT has been gradually increasing since the late 1990s, whereas the use of related BMT/PBSCT has remained stable. The use of unrelated BMT has been steadily decreasing.

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Bone Marrow and Stem Cell Transplant ID - 14163 Y1 - 2015 PB - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14163/all/Bone_Marrow_and_Stem_Cell_Transplant ER -