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- A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
- Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).
Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ∼70% of primary immune deficiencies.
Genetic defects have been identified in many cases, which are identified in the “Differential Diagnosis.”