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Hypogammaglobulinemia is a topic covered in the Select 5-Minute Pediatrics Topics.

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  • A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
  • Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).


Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ∼70% of primary immune deficiencies.

Risk Factors

Genetic defects have been identified in many cases, which are identified in the “Differential Diagnosis.”

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Cabana, Michael D., editor. "Hypogammaglobulinemia." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/all/Hypogammaglobulinemia.
Hypogammaglobulinemia. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/all/Hypogammaglobulinemia. Accessed April 21, 2019.
Hypogammaglobulinemia. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/all/Hypogammaglobulinemia
Hypogammaglobulinemia [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 April 21]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/all/Hypogammaglobulinemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hypogammaglobulinemia ID - 14104 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/all/Hypogammaglobulinemia PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -