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Transient Tachypnea of the Newborn

Transient Tachypnea of the Newborn is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

  • Early onset of tachypnea (respiratory rate >60 breaths/minute) in the newborn following an uneventful delivery
  • Symptoms of respiratory distress including mild retractions, expiratory grunting, and nasal flaring may occur. Cyanosis is rarely involved.

Epidemiology

Incidence

  • Estimated 4–6 per 1,000 live births
  • Incidence is likely underestimated.
  • Most common cause of respiratory distress in newborns
  • Higher in males

Risk Factors

  • Early gestation
  • Cesarean section delivery (with or without preceding labor)
  • Male gender
  • Maternal diabetes
  • Macrosomia
  • Low birth weight
  • Maternal history of asthma
  • Unexplained transient tachypnea of the newborn (TTN) in individuals belonging to the same family suggests a genetic predisposition.

General Prevention

  • Vaginal delivery should be recommended in the absence of maternal or fetal indications for cesarean section.
  • Elective cesarean section before 39 weeks’ gestation should be avoided.

Etiology

  • During fetal life, pulmonary epithelial cells are secretory, delivering chloride into the alveolar space.
  • Sodium and water follow chloride into the alveoli, establishing and maintaining fetal lung fluid.
  • During labor and delivery, fetal lung fluid is absorbed through a variety of proposed mechanisms:
    • Epithelial cells transition from secretory cells to absorptive cells in response to circulating epinephrine levels, which trigger opening of epithelial sodium channels (ENaC).
    • Compression of the fetal thorax from uterine contractions and passage through the vaginal canal contributes to removal of fluid from the lungs through the pulmonary circulation.
    • Prostaglandin-mediated dilation of lymphatic vessels occurs with resultant absorption of interstitial lung fluid into the lymphatic system.
  • TTN occurs when there is inadequate fluid clearance from the lungs.
  • It is believed that this excess interstitial lung fluid contributes to decreased lung compliance.

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Citation

Cabana, Michael D., editor. "Transient Tachypnea of the Newborn." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14077/all/Transient_Tachypnea_of_the_Newborn.
Transient Tachypnea of the Newborn. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14077/all/Transient_Tachypnea_of_the_Newborn. Accessed April 25, 2019.
Transient Tachypnea of the Newborn. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14077/all/Transient_Tachypnea_of_the_Newborn
Transient Tachypnea of the Newborn [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 April 25]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14077/all/Transient_Tachypnea_of_the_Newborn.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Transient Tachypnea of the Newborn ID - 14077 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14077/all/Transient_Tachypnea_of_the_Newborn PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -