Avascular (Aseptic) Necrosis of the Femoral Head (Hip)

Avascular (Aseptic) Necrosis of the Femoral Head (Hip) is a topic covered in the Select 5-Minute Pediatrics Topics.

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Basics

Description

  • Avascular (aseptic) necrosis results from the interruption of the blood supply to bone (either traumatic or nontraumatic occlusion).
  • The femoral head is the most common site.
  • A particular type of self-limiting idiopathic avascular necrosis of the hip that occurs in children is known as Perthes disease (see the “Perthes Disease” chapter).

Risk Factors

Genetics

Variable, depending on cause

Pathophysiology

  • Death and necrosis of bone with gradual return of blood supply
  • Necrotic bone gradually resorbed and replaced by new bone
  • During bone resorption, structural integrity of femoral head may be reduced, leading to collapse.

Etiology

  • Traumatic
    • Hip fracture
    • Hip dislocation
    • Slipped capital femoral epiphysis
    • Complication of casting, bracing, surgery
  • Nontraumatic
    • Idiopathic (older, after physeal closure); similar to adult avascular necrosis
    • Idiopathic (younger, before physeal closure, Perthes disease)
    • Caisson disease
    • Sickle cell disease
    • Septic arthritis
    • Steroids or chemotherapy
    • Malignancy (leukemia)
    • Gaucher disease
    • Viral infection (HIV, CMV)
    • Radiation therapy
    • Hypercoagulable states

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Citation

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TY - ELEC T1 - Avascular (Aseptic) Necrosis of the Femoral Head (Hip) ID - 14070 Y1 - 2015 PB - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14070/all/Avascular__Aseptic__Necrosis_of_the_Femoral_Head__Hip_ ER -