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Jaundice is a topic covered in the Select 5-Minute Pediatrics Topics.

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  • Jaundice: a yellow or green/yellow hue to the skin, sclerae, and mucous membranes which can be appreciated at serum bilirubin levels >2 mg/dL. Intensity of color is directly related to the serum bilirubin level.
  • Unconjugated bilirubin: 80% is due to hemoglobin turnover and 20% is from degradation of hepatic and renal heme proteins. It is a hydrophobic compound that must be carried to the liver by albumin for processing.
  • Conjugated bilirubin: conjugated to glucuronic acid in the liver, a water-soluble derivative that helps lipid emulsification and absorption
  • Conjugated hyperbilirubinemia (direct hyperbilirubinemia): a conjugated bilirubin of >2 mg/dL or >20% of the total bilirubin


The most common causes of pathologic jaundice are as follows:

  • Newborn period: biliary atresia, idiopathic neonatal hepatitis, α-1-antitrypsin deficiency, infection
  • Older child: autoimmune hepatitis, viral hepatitis, Wilson disease, biliary obstruction

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Cabana, Michael D., editor. "Jaundice." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14067/1.1/Jaundice.
Jaundice. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14067/1.1/Jaundice. Accessed August 18, 2019.
Jaundice. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14067/1.1/Jaundice
Jaundice [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 August 18]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14067/1.1/Jaundice.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Jaundice ID - 14067 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14067/1.1/Jaundice PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -