Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:
-- The first section of this topic is shown below --
Leukocytosis refers to a total white blood cell (WBC) count above the normal range for age.
- Very low-birth-weight neonates
- Immunodeficiencies or immunocompromised states
- Inflammatory disorders
- Autoimmune disorders
Children with trisomy 21 (Down syndrome) have an increased risk of developing transient myeloproliferative disorder (TMD) or leukemoid reactions.
Leukocytosis results from increased marrow production, demargination, prolonged cell survival, and/or defective extravasculation in response to external stimuli or, less commonly, from an underlying marrow disorder.