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Jaundice (icterus)

Jaundice (icterus) is a topic covered in the Diagnosaurus.

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Unconjugated (indirect bilirubin)

  • Increased production: hemolysis, hematoma, pulmonary infarction
  • Impaired uptake and storage: posthepatitis hyperbilirubinemia, Gilbert's syndrome, Crigler-Najjar syndrome, drugs

Conjugated (direct bilirubin)

  • Biliary obstruction: choledocholithiasis, pancreatic tumor, biliary stricture, primary sclerosing cholangitis, biliary duct carcinoma
  • Hepatocellular damage or intrahepatic cholestasis: hepatitis (eg, alcoholic, viral), hepatic cirrhosis, biliary cirrhosis, drugs, sepsis, cholangitis, liver abscess, Budd-Chiari syndrome, infectious mononucleosis, spirochetal infection, infiltrative disease (tuberculosis, sarcoidosis, lymphoma), industrial toxins
  • Hereditary bilirubin excretion defect: Dubin-Johnson syndrome, Rotor's syndrome

Other causes of yellow skin

  • Carotenemia (excessive beta-carotene ingestion, especially in hypothyroidism)

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Last updated: December 1, 2014


Zeiger, Roni F.. "Jaundice (icterus)." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114695/all/Jaundice__icterus_.
Zeiger RF. Jaundice (icterus). Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114695/all/Jaundice__icterus_. Accessed July 15, 2019.
Zeiger, R. F. (2014). Jaundice (icterus). In Diagnosaurus. Available from https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114695/all/Jaundice__icterus_
Zeiger RF. Jaundice (icterus) [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 July 15]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114695/all/Jaundice__icterus_.
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TY - ELEC T1 - Jaundice (icterus) ID - 114695 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114695/all/Jaundice__icterus_ PB - McGraw-Hill Education ET - 4 DB - Medicine Central DP - Unbound Medicine ER -