Hypercoagulable state

Hypercoagulable state is a topic covered in the Diagnosaurus.

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Etiology

Acquired

  • Immobility or postoperative state
  • Cancer
  • Inflammatory disorders, eg, ulcerative colitis
  • Myeloproliferative disorder, eg, polycythemia vera, essential thrombocytosis
  • Estrogens, pregnancy
  • Heparin-induced thrombocytopenia
  • Lupus anticoagulant
  • Anticardiolipin antibodies
  • Nephrotic syndrome
  • Paroxysmal nocturnal hemoglobinuria
  • Disseminated intravascular coagulation
  • Congestive heart failure
Congenital
  • Activated protein C resistance, eg, Factor V Leiden
  • Prothrombin 20210 mutation
  • Antithrombin III deficiency
  • Protein C deficiency
  • Protein S deficiency
  • Hyperhomocysteinemia
  • Dysfibrinogenemia
  • Abnormal plasminogen

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Last updated: December 1, 2014