PTT increased

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Etiology

Congenital factor deficiencies

  • Contact factors (no clinical bleeding)
  • Factor XII (no clinical bleeding)
  • Factor XI
  • Factor IX (hemophilia B)
  • Factor VIII (hemophilia A)
  • Factor VIII (von Willebrand's disease)
  • Factor I (afibrinogenemia)

Anticoagulants

  • Factor VIII inhibitor (postpartum, idiopathic, or after factor VIII infusions)
  • Lupus anticoagulant (no clinical bleeding)
  • Heparin
  • Warfarin (PT increased more than PTT)

Other

  • Disseminated intravascular coagulation (PT & PTT increased)
  • Liver disease (PT increased more than PTT)
  • Vitamin K deficiency (PT increased more than PTT)

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Etiology

Congenital factor deficiencies

  • Contact factors (no clinical bleeding)
  • Factor XII (no clinical bleeding)
  • Factor XI
  • Factor IX (hemophilia B)
  • Factor VIII (hemophilia A)
  • Factor VIII (von Willebrand's disease)
  • Factor I (afibrinogenemia)

Anticoagulants

  • Factor VIII inhibitor (postpartum, idiopathic, or after factor VIII infusions)
  • Lupus anticoagulant (no clinical bleeding)
  • Heparin
  • Warfarin (PT increased more than PTT)

Other

  • Disseminated intravascular coagulation (PT & PTT increased)
  • Liver disease (PT increased more than PTT)
  • Vitamin K deficiency (PT increased more than PTT)

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Last updated: December 1, 2014