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Hemolytic anemia

Hemolytic anemia is a topic covered in the Diagnosaurus.

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Etiology

Coombs positive (immune)

  • Autoimmune, drugs, infection, lymphoproliferative disease, Rh or ABO incompatibility

Coombs negative

  • Intrinsic red cell disease
    • Abnormal hemoglobin: sickle cell disease, thalassemia, methemoglobinemia
    • Membrane defect: hereditary spherocytosis, hereditary elliptocytosis, paroxysmal nocturnal hemoglobinuria
    • Enzyme defect: G6PD deficiency, pyruvate kinase deficiency
  • Extrinsic disease
    • Microangiopathic hemolytic anemia: thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, disseminated intravascular coagulation, prosthetic valve hemolysis, metastatic adenocarcinoma, vasculitis, malignant hypertension, HELLP syndrome
    • Splenic sequestration
    • Infection: malaria, Clostridium, Borrelia
    • Burns

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Last updated: December 1, 2014

Citation

Zeiger, Roni F.. "Hemolytic Anemia." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114648/1/Hemolytic_anemia.
Zeiger RF. Hemolytic anemia. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114648/1/Hemolytic_anemia. Accessed June 18, 2019.
Zeiger, R. F. (2014). Hemolytic anemia. In Diagnosaurus. Available from https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114648/1/Hemolytic_anemia
Zeiger RF. Hemolytic Anemia [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 June 18]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114648/1/Hemolytic_anemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hemolytic anemia ID - 114648 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114648/1/Hemolytic_anemia PB - McGraw-Hill Education ET - 4 DB - Medicine Central DP - Unbound Medicine ER -