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Primary amenorrhea

Primary amenorrhea is a topic covered in the Diagnosaurus.

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Hypothalamic-pituitary causes (low-normal FSH)

  • Idiopathic delayed puberty
  • Pituitary tumor
  • Hypothalamic amenorrhea, eg, stress, weight change, exercise
  • Anorexia nervosa
  • Hypothyroidism
  • Cushing's syndrome
  • GnRH or gonadotropin deficiency, eg, Kallmann syndrome
  • Craniopharyngioma

Excess testosterone (low-normal FSH)

  • Adrenal tumor or adrenal hyperplasia
  • Polycystic ovary syndrome
  • Ovarian tumor
  • Androgenic steroids

Ovarian causes (high FSH)

  • Gonadal dysgenesis, eg, Turner syndrome
  • Autoimmune ovarian failure
  • Rare ovarian enzyme deficiencies

Pseudohermaphroditism (high LH)

  • Testosterone synthesis defect
  • Complete androgen resistance (testicular feminization)

Anatomic defect (normal FSH)

  • Vaginal agenesis, absent uterus, atrophic endometrium, imperforate hymen

Pregnancy (high hCG)

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Last updated: December 1, 2014


Zeiger, Roni F.. "Primary Amenorrhea." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea.
Zeiger RF. Primary amenorrhea. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea. Accessed April 18, 2019.
Zeiger, R. F. (2014). Primary amenorrhea. In Diagnosaurus. Available from https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea
Zeiger RF. Primary Amenorrhea [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 18]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Primary amenorrhea ID - 114541 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea PB - McGraw-Hill Education ET - 4 DB - Medicine Central DP - Unbound Medicine ER -