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    Primary amenorrhea

    Primary amenorrhea is a topic covered in the Diagnosaurus.

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    Etiology

    Hypothalamic-pituitary causes (low-normal FSH)

    • Idiopathic delayed puberty
    • Pituitary tumor
    • Hypothalamic amenorrhea, eg, stress, weight change, exercise
    • Anorexia nervosa
    • Hypothyroidism
    • Cushing's syndrome
    • GnRH or gonadotropin deficiency, eg, Kallmann syndrome
    • Craniopharyngioma

    Excess testosterone (low-normal FSH)

    • Adrenal tumor or adrenal hyperplasia
    • Polycystic ovary syndrome
    • Ovarian tumor
    • Androgenic steroids

    Ovarian causes (high FSH)

    • Gonadal dysgenesis, eg, Turner syndrome
    • Autoimmune ovarian failure
    • Rare ovarian enzyme deficiencies

    Pseudohermaphroditism (high LH)

    • Testosterone synthesis defect
    • Complete androgen resistance (testicular feminization)

    Anatomic defect (normal FSH)

    • Vaginal agenesis, absent uterus, atrophic endometrium, imperforate hymen

    Pregnancy (high hCG)

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    Last updated: December 1, 2014

    Citation

    Zeiger, Roni F.. "Primary Amenorrhea." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea.
    Zeiger RF. Primary amenorrhea. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea. Accessed April 18, 2019.
    Zeiger, R. F. (2014). Primary amenorrhea. In Diagnosaurus. Available from https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea
    Zeiger RF. Primary Amenorrhea [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 18]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Primary amenorrhea ID - 114541 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114541/all/Primary_amenorrhea PB - McGraw-Hill Education ET - 4 DB - Medicine Central DP - Unbound Medicine ER -