Diagnosaurus
Hyperuricemia, endogenous
Hyperuricemia, endogenous is a topic covered in the Diagnosaurus.
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Etiology
Primary hyperuricemia
- Increased production of purine
- Idiopathic
- Specific enzyme defects (eg, Lesch-Nyhan syndrome, glycogen storage diseases)
- Decreased renal clearance of uric acid (idiopathic)
Secondary hyperuricemia
- Increased purine catabolism and turnover
- Myeloproliferative disorders
- Lymphoproliferative disorders
- Carcinoma and sarcoma (disseminated)
- Chronic hemolytic anemias
- Cytotoxic drugs
- Psoriasis
- Decreased renal clearance of uric acid
- Intrinsic kidney disease
- Functional impairment of tubular transport:
- Drug-induced (eg, thiazides, probenecid)
- Hyperlacticacidemia (eg, lactic acidosis, alcoholism)
- Hyperketoacidemia (eg, diabetic ketoacidosis, starvation)
- Diabetes insipidus (vasopressin-resistant)
- Bartter's syndrome
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Etiology
Primary hyperuricemia
- Increased production of purine
- Idiopathic
- Specific enzyme defects (eg, Lesch-Nyhan syndrome, glycogen storage diseases)
- Decreased renal clearance of uric acid (idiopathic)
Secondary hyperuricemia
- Increased purine catabolism and turnover
- Myeloproliferative disorders
- Lymphoproliferative disorders
- Carcinoma and sarcoma (disseminated)
- Chronic hemolytic anemias
- Cytotoxic drugs
- Psoriasis
- Decreased renal clearance of uric acid
- Intrinsic kidney disease
- Functional impairment of tubular transport:
- Drug-induced (eg, thiazides, probenecid)
- Hyperlacticacidemia (eg, lactic acidosis, alcoholism)
- Hyperketoacidemia (eg, diabetic ketoacidosis, starvation)
- Diabetes insipidus (vasopressin-resistant)
- Bartter's syndrome
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Citation
Zeiger, Roni F.. "Hyperuricemia, Endogenous." Diagnosaurus, 4th ed., McGraw-Hill Education, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
Zeiger RFR. Hyperuricemia, endogenous. Diagnosaurus. McGraw-Hill Education; 2015. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous. Accessed March 30, 2023.
Zeiger, R. F. (2015). Hyperuricemia, endogenous. In Diagnosaurus (4th ed.). McGraw-Hill Education. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous
Zeiger RFR. Hyperuricemia, Endogenous [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2015. [cited 2023 March 30]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
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