Diagnosaurus
Hyperuricemia, endogenous
Etiology
Primary hyperuricemia
- Increased production of purine
- Idiopathic
- Specific enzyme defects (eg, Lesch-Nyhan syndrome, glycogen storage diseases)
- Decreased renal clearance of uric acid (idiopathic)
Secondary hyperuricemia
- Increased purine catabolism and turnover
- Myeloproliferative disorders
- Lymphoproliferative disorders
- Carcinoma and sarcoma (disseminated)
- Chronic hemolytic anemias
- Cytotoxic drugs
- Psoriasis
- Decreased renal clearance of uric acid
- Intrinsic kidney disease
- Functional impairment of tubular transport:
- Drug-induced (eg, thiazides, probenecid)
- Hyperlacticacidemia (eg, lactic acidosis, alcoholism)
- Hyperketoacidemia (eg, diabetic ketoacidosis, starvation)
- Diabetes insipidus (vasopressin-resistant)
- Bartter's syndrome
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Last updated: December 1, 2014
Citation
Zeiger, Roni F.. "Hyperuricemia, Endogenous." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
Zeiger RFR. Hyperuricemia, endogenous. Diagnosaurus. McGraw-Hill Education; 2014. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous. Accessed May 17, 2025.
Zeiger, R. F. (2014). Hyperuricemia, endogenous. In Diagnosaurus (4th ed.). McGraw-Hill Education. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous
Zeiger RFR. Hyperuricemia, Endogenous [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2025 May 17]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Hyperuricemia, endogenous
ID - 114081
A1 - Zeiger,Roni F,
Y1 - 2014/12/01/
BT - Diagnosaurus
UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous
PB - McGraw-Hill Education
ET - 4
DB - Medicine Central
DP - Unbound Medicine
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