allergy, cold and cough remedies
Seasonal allergic rhinitis.
Antagonizes the effects of histamine at histamine1 receptor sites; does not bind to or inactivate histamine.
Decreased symptoms of histamine excess including rhinorrhea, sneezing, and nasal itching.
Absorption: 57% absorbed from nasal mucosa.
Metabolism and Excretion: Minimal metabolism; 70% eliminated in urine mostly as unchanged drug; 17% fecal elimination.
Half-life: 8–12 hr.
- None noted.
Use Cautiously in:
- Nasal pathology other than allergic rhinitis
- OB: Safety not established in pregnancy
- Lactation: Safety not established in breastfeeding
- Pedi: Children <6 yr (safety not established).
- Geri: Dose cautiously in older adults; consider age-related ↓ in organ function and concurrent medications
Adverse Reactions/Side Effects
EENT: epistaxis, nasal perforation, nasal ulcerations, pharyngolaryngeal pain, postnasal drip
GI: bitter taste
Neuro: drowsiness, headache
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
↑ CNS depression may occur with alcohol ; avoid concurrent use.
Intranasal (Adults and Children ≥ 12 yr): 2 sprays in each nostril twice daily.
Intranasal (Children 6–11 yr): 1 spray in each nostril twice daily.
Availability (generic available)
Nasal spray: 665 mcg/spray in 30.5-g bottle (provides 240 sprays)
- Assess for symptoms of seasonal allergic rhinitis (sneezing, runny nose, nasal itching) prior to and during therapy.
- Administer 2 sprays per nostril twice daily.
- Instruct patient to prime nasal spray by releasing 5 sprays or spraying until a fine mist appears before initial use. If unit has not been used within 7 days, re-prime with 2 sprays. Advise patient to discard nasal device after 240 sprays (30 days) even if bottle is not completely empty; correct amount of medication cannot be assured after 240 sprays.
- May cause drowsiness. Advise patient to avoid driving or other activities that require alertness until response to medication is known.
- Instruct patient to avoid concurrent use of alcohol or other CNS depressants.
- Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Relief of symptoms of seasonal allergic rhinitis (rhinorrhea, sneezing, nasal itching).
Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Complete Product Information.