- Peyronie disease (PD) is a progressive connective tissue disorder affecting the tunica albuginea.
- Results in aberrant fibrosis and inelastic scar (plaque) formation due to abnormal wound healing
- Formation of plaque results in penile deformities: curvature, indentation, shortening, hourglass configuration, and/or painful erections.
- PD is often accompanied with erectile dysfunction (ED) (1)[C].
- Named after 18th-century French physician Francois de la Peyronie
- The most common plaque location is on the dorsal aspect of the penis followed by lateral then ventral (1)[C].
- Curvature can range from mild to severe and may preclude sexual intercourse and cause psychological distress.
- Synonyms: acquired penile curvature, penile induration
- Between 2% and 9% (1)
- Reported in up to 9% of men >40 years of age (1,2)
- May have significant effects of quality of life (1)
- Associated with high rates of depression, relationship stressors, low self-esteem (1)
Etiology and Pathophysiology
- Exact etiology unknown; generally thought to be secondary to trauma (1)[C]
- Theory: Microtrauma in men with genetic predisposition leads to inflammation of the tunica albuginea, then collagen deposition, and eventually fibrosis in the form of a plaque (1)[C].
- Acute phase
- 6 to 18 months of acute inflammation eventually leading to fibrosis and plaque formation
- Painful erections that resolve spontaneously
- Chronic phase
- Complete spontaneous resolution of PD is uncommon (1,2)[C].
- Most common presenting symptoms: penile pain, erection deformity, palpable plaque, ED (1)[C]
Commonly Associated Conditions
- Dupuytren contracture
- Ledderhose disease of plantar fascia
- Tympanosclerosis of eardrum
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