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- Peyronie disease (PD) is a progressive connective tissue disorder affecting the tunica albuginea.
- Results in aberrant fibrosis and inelastic scar (plaque) formation due to abnormal wound healing
- Formation of plaque results in penile deformities: curvature, indentation, shortening, hourglass configuration, and/or painful erections.
- PD is often accompanied with erectile dysfunction (ED).
- Named after 18th-century French physician Francois de la Peyronie
- The most common plaque location is on the dorsal aspect of the penis followed by lateral then ventral.
- Curvature can range from mild to severe and may preclude sexual intercourse and cause psychological distress.
- Synonyms: acquired penile curvature, penile induration
- Between 3% and 9%
- Reported in up to 9% of men >40 years of age (1)
- Mean age of diagnosis: 53 years in white males
- Estimated prevalence: 3–20% of men of all ages
- Higher prevalence of up to 22.3% reported in patients with diabetes mellitus
- Reported prevalence of concomitant ED: 37–58%
Etiology and Pathophysiology
- Exact etiology unknown; generally thought to be secondary to trauma
- Theory: Microtrauma in men with genetic predisposition leads to inflammation of the tunica albuginea, then collagen deposition, and eventually fibrosis in the form of a plaque.
- Acute phase
- Chronic phase
- Stable plaque formation and angulation
- Resolution of pain
- Complete spontaneous resolution of PD is uncommon.
- Most common presenting symptoms: penile pain, erection deformity, palpable plaque, ED
- Genetic predisposition/HLA-B7
Commonly Associated Conditions
- Dupuytren contracture
- Ledderhose disease of plantar fascia
- Tympanosclerosis of eardrum