Loin Pain/Hematuria Syndrome

Loin Pain/Hematuria Syndrome is a topic covered in the 5-Minute Clinical Consult.

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Basics

Description

  • A rare and poorly understood syndrome characterized by unexplained chronic, severe, intermittent or persistent, unilateral or bilateral loin/flank pain with microscopic or gross hematuria
  • It is a diagnosis of exclusion.
  • Treatment requires reassurance, careful management of analgesia, and psychological support.

Epidemiology

Incidence
Unknown


Prevalence
  • 0.01%
  • Range: 10 to 70 years
  • 70% of cases are in females.
  • More common in white female in 20s to 30s

Etiology and Pathophysiology

  • Uncertain
  • Several hypotheses have been proposed such as microvascular abnormalities, complement activation on arterioles, renal vasospasm, veno-caliceal fistula, abnormal ureteral peristalsis, intratubular crystal formation, abnormal platelet function, or psychogenic nature.
  • Glomerular basement membrane abnormalities (too thick or thin) leading to glomerular wall rupture and passage of red blood cell (RBC) into the urinary space, causing tubular obstruction and back leak of glomerular filtrate with resultant parenchymal edema and stretching of renal capsule have been proposed.

Genetics
No report of genetic involvement

Risk Factors

Unknown

General Prevention

N/A

Commonly Associated Conditions

  • Somatoform disorder
  • 50% of patients have a history of nephrolithiasis.

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Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Loin Pain/Hematuria Syndrome ID - 816807 ED - Baldor,Robert A, ED - Domino,Frank J, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816807/all/Loin_Pain_Hematuria_Syndrome PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -