Type your tag names separated by a space and hit enter

Cutaneous T-Cell Lymphoma, Mycosis Fungoides

Cutaneous T-Cell Lymphoma, Mycosis Fungoides is a topic covered in the 5-Minute Clinical Consult.

To view the entire topic, please or purchase a subscription.

Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:

Medicine Central

-- The first section of this topic is shown below --


Cutaneous T-cell lymphoma (CTCL) is a rare and typically indolent mature T-cell lymphoma presenting primarily in the skin. This disease involves overlap of the disciplines of dermatology, medical oncology, and radiation oncology.


  • A heterogeneous group of relatively uncommon extranodal non-Hodgkin lymphomas
  • This topic focuses on mycosis fungoides (MF), the most common subtype of cutaneous lymphoma. Other subtypes include Sézary syndrome and primary cutaneous anaplastic large cell lymphoma (ALCL). For other subtypes, please consult the Reference section.


  • Median age at diagnosis is 55 to 60 years; however, it can occur in children and young adults.
  • Male-to-female ratio = 2:1
  • Incidence is higher in African Americans.

  • 0.6 cases/100,000/year
  • ~4% of all non-Hodgkin lymphoma cases

Etiology and Pathophysiology

  • Unknown but thought to be due to genetic and epigenetic abnormalities
  • Infiltration of activated and malignant T cells in the skin
  • Cytokines, such as interleukin (IL)-4 and IL-5, which can lead to eosinophilia and atopy-like symptoms

  • Clonal T-cell receptor (TCR) gene rearrangements are detected in most cases.
  • No recurrent, MF-specific chromosomal translocations have been identified.
  • Loss at chromosome 10q and abnormalities in the tumor suppressor genes p15, p16, and p53 are common.
  • Epigenetic changes may play an important role (1)[A].

Risk Factors

Possible risk factors include viral infection (HTLV-1, EBV) or solvent/chemical exposure.

-- To view the remaining sections of this topic, please or purchase a subscription --


Stephens, Mark B., et al., editors. "Cutaneous T-Cell Lymphoma, Mycosis Fungoides." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816085/all/Cutaneous_T_Cell_Lymphoma__Mycosis_Fungoides.
Cutaneous T-Cell Lymphoma, Mycosis Fungoides. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816085/all/Cutaneous_T_Cell_Lymphoma__Mycosis_Fungoides. Accessed April 26, 2019.
Cutaneous T-Cell Lymphoma, Mycosis Fungoides. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816085/all/Cutaneous_T_Cell_Lymphoma__Mycosis_Fungoides
Cutaneous T-Cell Lymphoma, Mycosis Fungoides [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 26]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816085/all/Cutaneous_T_Cell_Lymphoma__Mycosis_Fungoides.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Cutaneous T-Cell Lymphoma, Mycosis Fungoides ID - 816085 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816085/all/Cutaneous_T_Cell_Lymphoma__Mycosis_Fungoides PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -