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Arthritis, Rheumatoid (RA)
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Basics
Description
- Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily causing synovial inflammation leading to the destruction of bone and cartilage (1).
- Classification: based on the duration of disease (1)
- Early: ≤6 months
- Established: ≥6 months
- Based on the disease activity: low, moderate, high, or remission
Epidemiology
Incidence
Annual incidence: United States is approximately 40/100,000 persons.
Prevalence
- Prevalence: 0.5–1% of the general population worldwide
- Female:male, 2:1
Etiology and Pathophysiology
The cause remains uncertain; often precipitated by stress or insult (e.g., infection, smoking, trauma)
Genetics
HLA-DRB1
Risk Factors
Females at a younger age (5th to 6th decade), first- and second-degree relative), North American regions, Native Americans, smoking, obesity, lower socioeconomic status infections
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Basics
Description
- Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily causing synovial inflammation leading to the destruction of bone and cartilage (1).
- Classification: based on the duration of disease (1)
- Early: ≤6 months
- Established: ≥6 months
- Based on the disease activity: low, moderate, high, or remission
Epidemiology
Incidence
Annual incidence: United States is approximately 40/100,000 persons.
Prevalence
- Prevalence: 0.5–1% of the general population worldwide
- Female:male, 2:1
Etiology and Pathophysiology
The cause remains uncertain; often precipitated by stress or insult (e.g., infection, smoking, trauma)
Genetics
HLA-DRB1
Risk Factors
Females at a younger age (5th to 6th decade), first- and second-degree relative), North American regions, Native Americans, smoking, obesity, lower socioeconomic status infections
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