Arthritis, Rheumatoid (RA)
To view the entire topic, please log in or purchase a subscription.
Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:
-- The first section of this topic is shown below --
Basics
Description
- Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily causing synovial inflammation leading to the destruction of bone and cartilage (1).
- Classification: based on the duration of disease (1)
- Early: ≤6 months
- Established: ≥6 months
- Based on the disease activity: low, moderate, high, or remission
Epidemiology
Incidence
Annual incidence: United States is approximately 40/100,000 persons.
Prevalence
- Prevalence: 0.5–1% of the general population worldwide
- Female:male, 2:1
Etiology and Pathophysiology
The cause remains uncertain; often precipitated by stress or insult (e.g., infection, smoking, trauma)
Genetics
HLA-DRB1
Risk Factors
Females at a younger age (5th to 6th decade), first- and second-degree relative), North American regions, Native Americans, smoking, obesity, lower socioeconomic status infections
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily causing synovial inflammation leading to the destruction of bone and cartilage (1).
- Classification: based on the duration of disease (1)
- Early: ≤6 months
- Established: ≥6 months
- Based on the disease activity: low, moderate, high, or remission
Epidemiology
Incidence
Annual incidence: United States is approximately 40/100,000 persons.
Prevalence
- Prevalence: 0.5–1% of the general population worldwide
- Female:male, 2:1
Etiology and Pathophysiology
The cause remains uncertain; often precipitated by stress or insult (e.g., infection, smoking, trauma)
Genetics
HLA-DRB1
Risk Factors
Females at a younger age (5th to 6th decade), first- and second-degree relative), North American regions, Native Americans, smoking, obesity, lower socioeconomic status infections
There's more to see -- the rest of this topic is available only to subscribers.