Patellofemoral Pain Syndrome (PFPS)
 BASICS
	BASICS
DESCRIPTION
- Pain in or around the patella that is aggravated with increased patellar loading (e.g., prolonged sitting, squatting, kneeling, or ascending/descending stairs); not attributable to other causes
- Synonyms: anterior knee or retropatellar pain syndrome, chondromalacia patellae, runner’s knee
- System(s) affected: musculoskeletal
EPIDEMIOLOGY
Prevalence
ETIOLOGY AND PATHOPHYSIOLOGY
Increased patellofemoral joint loading, which is often multifactorial (3):
- Patellar malalignment or maltracking (3)
- Abnormal anatomy (e.g., patella alta, trochlear dysplasia) (3)
- Quadriceps asymmetry, weakness and/or tightness (3)
- Hamstring tightness (3)
- Laxity of the patellofemoral joint or a tight lateral retinaculum (3)
- Increased hip joint internal rotation (3)
- Altered tibiofemoral joint mechanics (3)
RISK FACTORS
- Activities such as running, squatting, and climbing up and down stairs
- Sudden increase in activities
- Female gender
- Dynamic valgus
- Patellar instability
- Quadriceps weakness
- Foot abnormalities (e.g., pes pronatus, rearfoot eversion) (1)
- In adolescents: increased hip adduction strength, although this may represent increased activity level
- Factors of uncertain significance: age, height, weight, body mass index, body fat, Q angle, and hip weakness
GENERAL PREVENTION
Strengthening and stretching exercises, particularly hip abductors and terminal extension of the quadriceps
COMMONLY ASSOCIATED CONDITIONS
- Overuse injury
- Knee ligament injury/surgery
- Patellar tendinopathy
- Prolonged synovitis
- Iliotibial band friction syndrome
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Citation
Domino, Frank J., et al., editors. "Patellofemoral Pain Syndrome (PFPS)." 5-Minute Clinical Consult, 34th ed., Wolters Kluwer, 2026. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688808/all/Patellofemoral_Pain_Syndrome__PFPS_. 
Patellofemoral Pain Syndrome (PFPS). In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2026. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688808/all/Patellofemoral_Pain_Syndrome__PFPS_. Accessed October 31, 2025.
Patellofemoral Pain Syndrome (PFPS). (2026). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (34th ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688808/all/Patellofemoral_Pain_Syndrome__PFPS_
Patellofemoral Pain Syndrome (PFPS) [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2026. [cited 2025 October 31]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688808/all/Patellofemoral_Pain_Syndrome__PFPS_.
* Article titles in AMA citation format should be in sentence-case
TY  -  ELEC
T1  -  Patellofemoral Pain Syndrome (PFPS)
ID  -  1688808
ED  -  Domino,Frank J,
ED  -  Baldor,Robert A,
ED  -  Golding,Jeremy,
ED  -  Stephens,Mark B,
BT  -  5-Minute Clinical Consult, Updating
UR  -  https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688808/all/Patellofemoral_Pain_Syndrome__PFPS_
PB  -  Wolters Kluwer
ET  -  34
DB  -  Medicine Central
DP  -  Unbound Medicine
ER  -  

 5-Minute Clinical Consult
5-Minute Clinical Consult

