Description

• A disorder of keratinization
• Lesions of the skin with conical papules of a red and brown color surrounding the hair follicle
• Edges may become raised over time (1).
• Typically found in 30 to 40 year olds (2)
• Commonly located on the arms and legs

Etiology and Pathophysiology

Proliferation of atypical keratinocytes from a mutant clonal cell line

Genetics

• Genetic studies have revealed mutation of MVK (3).
• Mutation of keratinocyte proliferation and differentiation (3)
• Autosomal dominant with variable penetrance (1)

Risk Factors

• UV-light exposure (2)
• Male sex (1)
• Immune suppression (1)
• Infection (1)

General Prevention

Sunscreen and avoidance of UV exposure (2)

Commonly Associated Conditions

Skin malignancies in up to 10% of people (1)