Meningitis, Viral

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Basics

Description

  • A clinical syndrome characterized by fever with signs/symptoms of acute meningeal inflammation resulting from an identified viral infection
  • Viral meningitis (VM) is the most common cause of aseptic meningitis (no identifiable bacterial pathogen in CSF).
  • System(s) affected: nervous

Epidemiology

Incidence
  • Estimated 30,000 to 75,000 VM cases and 26,000 to 42,000 VM hospitalizations annually in United States
  • Most common form of infectious meningitis
    • The annual incidence of VM is higher than all other causes of meningitis combined.
  • Peaks June 1 to October 31
    • Nonpolio enteroviruses and arthropod-borne viruses predominate in warm months.
    • Mumps- and influenza-related meningitis usually occur in the winter and spring in epidemic form.

Etiology and Pathophysiology

  • In immunocompetent hosts, VM is generally caused by a virus with neurotropic predilection.
    • Less commonly, direct neural transmission occurs from an acute flare of a chronic viral illness (such as HSV) already present in an immunocompetent host.
  • 85–95% of VM cases are caused by enterovirus family, including coxsackievirus A and B, echovirus, and enterovirus A71. These are typically transmitted via the fecal-oral route.
  • Less common: HSV-1, HSV-2, VZV, adenovirus, lymphocytic choriomeningitis virus (LCMV), CMV, EBV, HIV, parvovirus B19, mumps
  • Arthropod-borne viruses: arboviruses such as West Nile virus, St. Louis encephalitis virus
  • Recurrent benign lymphocytic (Mollaret) meningitis is generally associated with HSV-2 (80% of cases).
  • A single case report has identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) as a cause of meningitis.

Genetics
None identified

Risk Factors

  • Close contact with known cases of VM
  • Age (most common in children <1 years with second peak in children >5 years)
    • VM is 20 times more common in children age <1 than in older children, adolescents and adults.
  • Immunocompromised host (patients more susceptible to CMV, HSV, and adenovirus)

Geriatric Considerations
Cases of VM in the elderly are rare (most common cause is VZV, HSV); consider alternative diagnoses (e.g., carcinomatous meningitis, medication-induced aseptic meningitis).

General Prevention

  • Limit exposure to known hosts; practice hand washing and general hygiene procedures.
  • Avoid sharing drinks/cups and silverware with others, especially those who are ill.
  • Avoid exposure to mosquitos and ticks.

Commonly Associated Conditions

Encephalitis; neurologic deficits; myopericarditis; neonatal enteroviral sepsis

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Basics

Description

  • A clinical syndrome characterized by fever with signs/symptoms of acute meningeal inflammation resulting from an identified viral infection
  • Viral meningitis (VM) is the most common cause of aseptic meningitis (no identifiable bacterial pathogen in CSF).
  • System(s) affected: nervous

Epidemiology

Incidence
  • Estimated 30,000 to 75,000 VM cases and 26,000 to 42,000 VM hospitalizations annually in United States
  • Most common form of infectious meningitis
    • The annual incidence of VM is higher than all other causes of meningitis combined.
  • Peaks June 1 to October 31
    • Nonpolio enteroviruses and arthropod-borne viruses predominate in warm months.
    • Mumps- and influenza-related meningitis usually occur in the winter and spring in epidemic form.

Etiology and Pathophysiology

  • In immunocompetent hosts, VM is generally caused by a virus with neurotropic predilection.
    • Less commonly, direct neural transmission occurs from an acute flare of a chronic viral illness (such as HSV) already present in an immunocompetent host.
  • 85–95% of VM cases are caused by enterovirus family, including coxsackievirus A and B, echovirus, and enterovirus A71. These are typically transmitted via the fecal-oral route.
  • Less common: HSV-1, HSV-2, VZV, adenovirus, lymphocytic choriomeningitis virus (LCMV), CMV, EBV, HIV, parvovirus B19, mumps
  • Arthropod-borne viruses: arboviruses such as West Nile virus, St. Louis encephalitis virus
  • Recurrent benign lymphocytic (Mollaret) meningitis is generally associated with HSV-2 (80% of cases).
  • A single case report has identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) as a cause of meningitis.

Genetics
None identified

Risk Factors

  • Close contact with known cases of VM
  • Age (most common in children <1 years with second peak in children >5 years)
    • VM is 20 times more common in children age <1 than in older children, adolescents and adults.
  • Immunocompromised host (patients more susceptible to CMV, HSV, and adenovirus)

Geriatric Considerations
Cases of VM in the elderly are rare (most common cause is VZV, HSV); consider alternative diagnoses (e.g., carcinomatous meningitis, medication-induced aseptic meningitis).

General Prevention

  • Limit exposure to known hosts; practice hand washing and general hygiene procedures.
  • Avoid sharing drinks/cups and silverware with others, especially those who are ill.
  • Avoid exposure to mosquitos and ticks.

Commonly Associated Conditions

Encephalitis; neurologic deficits; myopericarditis; neonatal enteroviral sepsis

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