Vaginal Bleeding during Pregnancy
- Vaginal bleeding during pregnancy has many causes and ranges in severity from benign with normal pregnancy outcome to life-threatening for both infant and mother.
- Etiology can be from the vagina, cervix, uterus, fetus, or placenta. The differential diagnosis is guided by the gestational age of the fetus.
- In early pregnancy: 7–25% of patients
- In late pregnancy: 0.3–2% of patients
Etiology and Pathophysiology
- Many times the cause is unknown.
- Anytime in pregnancy:
- Cervicitis (infectious or noninfectious)
- Vaginal or cervical trauma (including postcoital)
- Cervical lesion or neoplasia
- Hyperemia of cervix (increased blood flow from pregnancy)
- Early pregnancy:
- For up to 50% of early pregnancy bleeding, no cause is ever found.
- Ectopic pregnancy: leading cause of 1st-trimester maternal death in the United States. Risk factors: previous ectopic, trauma to fallopian tubes (tubal surgery, infection, tumor), congenital anomaly of tubes, in utero diethylstilbestrol (DES) exposure, current use of IUD, history of infertility, tobacco use
- Spontaneous abortion: risk factors: advanced maternal age (AMA), alcohol use, tobacco use, anesthetic gas, heavy caffeine use, cocaine use, chronic maternal diseases (poorly controlled diabetes mellitus [DM], celiac disease, autoimmune diseases such as antiphospholipid syndrome), short interconception time (3 to 6 months), current use of IUD, maternal infection (e.g., herpes simplex virus [HSV], gonorrhea, chlamydia, toxoplasmosis, listeriosis, HIV, syphilis, malaria), medications (e.g., retinoids, methotrexate, NSAIDs), multiple previous therapeutic abortions, previous spontaneous abortion, toxins (arsenic, lead, polyurethane), uterine abnormalities (congenital, adhesions, fibroids)
- Implantation bleeding: benign, about 6 days after fertilization
- Uterine fibroids
- Subchorionic bleeding: in late 1st trimester
- Low-lying placenta
- Gestational trophoblastic disease: hydatidiform mole (most common), choriocarcinoma, or placental-site trophoblastic tumors
- Late pregnancy:
- Bloody show of labor (mucus plug)
- Placenta previa: painless bleeding; occurs in 0.4% deliveries in the United States. Risk factors: previous history of placenta previa, previous uterine surgery (cesarean section, D&C), chronic hypertension, multiparity, multiple gestation, tobacco use, AMA
- Placental abruption: (typically) painful bleeding; occurs in 1–2% deliveries in the United States. Risk factors: previous placental abruption, 1st-trimester bleeding, hypertension, preeclampsia, multiple gestation, tobacco, cocaine or methamphetamine use, unexplained elevated maternal α-fetoprotein, poly- or oligohydramnios, AMA, trauma to abdomen, premature rupture of membranes, thrombophilia, short umbilical cord, male fetus, chorioamnionitis, nutritional deficiency
- Vasa previa: minimal bleeding with fetal distress; rare (1:2,500 deliveries). Risk factors: in vitro fertilization, multiple gestations, placental abnormalities (low-lying position, bilobate, succenturiate lobe, velamentous insertion of umbilical cord)
- Placenta accreta, increta, percreta: risk factors: uterine scar (e.g., from cesarean section, endometrial ablation, or D&C), current placenta previa, AMA, tobacco use, multiparity, uterine anomalies, uterine fibroids, hypertension
- Uterine rupture: vaginal bleeding, abnormal fetal heart rate, and disordered or hypertonic uterine contractions with or without pain. Risk factors: previous cesarean section (most common), trauma, use of oxytocin or prostaglandins, multiparity, external cephalic version, placental abruption, shoulder dystocia, placenta percreta, müllerian duct anomalies, history of pelvic radiation
See specific etiologies in earlier discussion.
- Address modifiable risk factors such as domestic violence and tobacco and drug use.
- If placenta or vasa previa, nothing per vagina
There's more to see -- the rest of this topic is available only to subscribers.
Domino, Frank J., et al., editors. "Vaginal Bleeding During Pregnancy." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2020. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688694/all/Vaginal_Bleeding_during_Pregnancy.
Vaginal Bleeding during Pregnancy. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2020. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688694/all/Vaginal_Bleeding_during_Pregnancy. Accessed May 29, 2023.
Vaginal Bleeding during Pregnancy. (2020). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (27th ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688694/all/Vaginal_Bleeding_during_Pregnancy
Vaginal Bleeding During Pregnancy [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2020. [cited 2023 May 29]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688694/all/Vaginal_Bleeding_during_Pregnancy.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Vaginal Bleeding during Pregnancy ID - 1688694 ED - Domino,Frank J, ED - Baldor,Robert A, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688694/all/Vaginal_Bleeding_during_Pregnancy PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -