Tinnitus

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Basics

Description

  • Tinnitus is a perceived sensation of sound in the absence of an external acoustic stimulus; often described as a ringing, hissing, buzzing, clicking, or whooshing
  • Derived from the Latin word tinnire, meaning “to ring”
  • May be heard in one or both ears or centrally within the head
  • Two types: subjective (most common) and objective tinnitus
    • Subjective tinnitus: perceived only by the patient; can be continuous, intermittent, or pulsatile
    • Objective tinnitus: audible to the examiner; rare
  • Primary tinnitus: idiopathic with or without sensorineural hearing loss (SNHL) (1)
  • Secondary tinnitus: associated with a specific cause (other than SNHL)

Epidemiology

Incidence

  • Incidence increasing in association with excessive noise exposure
  • Higher rates of tinnitus in smokers, hypertensives, diabetics, and obese patients

Prevalence

  • Tinnitus reported by 35 to 50 million adults in United States; although underreported, 12 million seek medical care.
  • Affects 10–15% of adults (2)
  • Prevalence increases with age and peaks in 6th decade.
  • Prevalence of 13–53% in general pediatric population
  • Ethnic: whites > blacks and Hispanics
  • Gender: males > females

Etiology and Pathophysiology

  • Precise pathophysiology is unknown; numerous theories have been proposed. Ototoxic agents or noise exposure damage hair cells so that there is abnormal neural activity in the auditory cortex.
  • Causes of secondary tinnitus (2):
    • Otologic: cholesteatoma, cerumen impaction, foreign body, middle ear effusion, otosclerosis, Ménière disease, vestibular schwannoma, patulous eustachian tube
    • Medications: anti-inflammatory agents (aspirin, NSAIDs); antimalarial agents, antimicrobial drugs (aminoglycosides, macrolides); antineoplastic agents, loop diuretics, miscellaneous drugs (antiarrhythmics, antiulcer, anticonvulsants, antihypertensives); anesthetics
    • Somatic: temporomandibular joint (TMJ) dysfunction, head or neck injury
    • Neurologic: multiple sclerosis, spontaneous intracranial hypertension, vestibular migraine, type I Chiari malformation, palatal myoclonus, idiopathic stapedial muscle spasm
    • Infectious: viral, bacterial, fungal
    • Metabolic: diabetes mellitus, dyslipidemia, vitamin B12 deficiency
    • Vascular: aortic or carotid stenosis, venous hum, arteriovenous fistula or malformation, vascular tumors, high cardiac output state (anemia)

Genetics
Limited evidence to support a genetic component

Risk Factors

  • Hearing loss (but can have tinnitus with normal hearing)
  • High-level noise exposure
  • Advanced age
  • Use of ototoxic medications (some are irreversible)
  • Otologic disease (otosclerosis, Ménière disease, cerumen impaction)
  • Depression and anxiety associated with increased odds of tinnitus

General Prevention

  • Avoid loud noise exposure and wear appropriate ear protection to prevent hearing loss.
  • Monitor ototoxic medications and avoid prescribing more than one ototoxic agent concurrently.

Commonly Associated Conditions

  • SNHL caused by presbycusis (age-associated hearing loss) or prolonged loud noise exposure
  • Conductive hearing loss due to cerumen, otosclerosis, cholesteatoma
  • Psychological disorders: depression, anxiety, insomnia, suicidal ideation
  • Despair, frustration, interference with concentration and social interactions, work hindrance

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Basics

Description

  • Tinnitus is a perceived sensation of sound in the absence of an external acoustic stimulus; often described as a ringing, hissing, buzzing, clicking, or whooshing
  • Derived from the Latin word tinnire, meaning “to ring”
  • May be heard in one or both ears or centrally within the head
  • Two types: subjective (most common) and objective tinnitus
    • Subjective tinnitus: perceived only by the patient; can be continuous, intermittent, or pulsatile
    • Objective tinnitus: audible to the examiner; rare
  • Primary tinnitus: idiopathic with or without sensorineural hearing loss (SNHL) (1)
  • Secondary tinnitus: associated with a specific cause (other than SNHL)

Epidemiology

Incidence

  • Incidence increasing in association with excessive noise exposure
  • Higher rates of tinnitus in smokers, hypertensives, diabetics, and obese patients

Prevalence

  • Tinnitus reported by 35 to 50 million adults in United States; although underreported, 12 million seek medical care.
  • Affects 10–15% of adults (2)
  • Prevalence increases with age and peaks in 6th decade.
  • Prevalence of 13–53% in general pediatric population
  • Ethnic: whites > blacks and Hispanics
  • Gender: males > females

Etiology and Pathophysiology

  • Precise pathophysiology is unknown; numerous theories have been proposed. Ototoxic agents or noise exposure damage hair cells so that there is abnormal neural activity in the auditory cortex.
  • Causes of secondary tinnitus (2):
    • Otologic: cholesteatoma, cerumen impaction, foreign body, middle ear effusion, otosclerosis, Ménière disease, vestibular schwannoma, patulous eustachian tube
    • Medications: anti-inflammatory agents (aspirin, NSAIDs); antimalarial agents, antimicrobial drugs (aminoglycosides, macrolides); antineoplastic agents, loop diuretics, miscellaneous drugs (antiarrhythmics, antiulcer, anticonvulsants, antihypertensives); anesthetics
    • Somatic: temporomandibular joint (TMJ) dysfunction, head or neck injury
    • Neurologic: multiple sclerosis, spontaneous intracranial hypertension, vestibular migraine, type I Chiari malformation, palatal myoclonus, idiopathic stapedial muscle spasm
    • Infectious: viral, bacterial, fungal
    • Metabolic: diabetes mellitus, dyslipidemia, vitamin B12 deficiency
    • Vascular: aortic or carotid stenosis, venous hum, arteriovenous fistula or malformation, vascular tumors, high cardiac output state (anemia)

Genetics
Limited evidence to support a genetic component

Risk Factors

  • Hearing loss (but can have tinnitus with normal hearing)
  • High-level noise exposure
  • Advanced age
  • Use of ototoxic medications (some are irreversible)
  • Otologic disease (otosclerosis, Ménière disease, cerumen impaction)
  • Depression and anxiety associated with increased odds of tinnitus

General Prevention

  • Avoid loud noise exposure and wear appropriate ear protection to prevent hearing loss.
  • Monitor ototoxic medications and avoid prescribing more than one ototoxic agent concurrently.

Commonly Associated Conditions

  • SNHL caused by presbycusis (age-associated hearing loss) or prolonged loud noise exposure
  • Conductive hearing loss due to cerumen, otosclerosis, cholesteatoma
  • Psychological disorders: depression, anxiety, insomnia, suicidal ideation
  • Despair, frustration, interference with concentration and social interactions, work hindrance

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