Pancreatitis, Chronic
Basics
Description
- Long-standing and progressive destruction of pancreatic tissue due to persistent inflammation
- Results in exocrine and/or endocrine insufficiency
- Major features
- Pain
- Malabsorption
- Diabetes mellitus (type 3)
- Increased risk of pancreatic cancer
Epidemiology
Incidence
- Predominant age: 35 to 45 years (usually related to alcohol abuse)
- Predominant sex: male > female
- Hospitalization more common for blacks than whites
Prevalence
8/10,000
Genetics
Hereditary pancreatitis is a rare condition with an autosomal dominant inheritance pattern; mutations in PRSS1 gene and SPINKI gene
General Prevention
- Avoid tobacco.
- Avoid excess alcohol.
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Citation
Domino, Frank J., et al., editors. "Pancreatitis, Chronic." 5-Minute Clinical Consult, 33rd ed., Wolters Kluwer, 2025. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688556/all/Pancreatitis__Chronic.
Pancreatitis, Chronic. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2025. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688556/all/Pancreatitis__Chronic. Accessed December 18, 2024.
Pancreatitis, Chronic. (2025). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (33rd ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688556/all/Pancreatitis__Chronic
Pancreatitis, Chronic [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2025. [cited 2024 December 18]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688556/all/Pancreatitis__Chronic.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Pancreatitis, Chronic
ID - 1688556
ED - Domino,Frank J,
ED - Baldor,Robert A,
ED - Golding,Jeremy,
ED - Stephens,Mark B,
BT - 5-Minute Clinical Consult, Updating
UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688556/all/Pancreatitis__Chronic
PB - Wolters Kluwer
ET - 33
DB - Medicine Central
DP - Unbound Medicine
ER -