Squamous Cell Carcinoma, Cutaneous

Descriptive text is not available for this image BASICS

DESCRIPTION

Cutaneous squamous cell cancer is the second most common keratinocyte carcinoma or nonmelanoma skin cancer after basal cell carcinoma.

EPIDEMIOLOGY

Keratinocyte carcinoma is the most common malignancy worldwide. Historically, cutaneous squamous cell carcinoma (SCC) has been thought to account for 20% of nonmelanoma skin cancers, thus it is considered to be the second most common malignancy after basal cell carcinoma. However, recent data indicate that the ratio of basal cell carcinoma to SCC is 1 in the U.S. Medicare population. An accurate incidence of cutaneous SCC is not known because this is not required to be reported to national cancer registries.

Incidence

  • The average age for incidence is around 60 years, more common in men.
  • Incidence increases the closer the person gets to the equator or higher altitude.

ETIOLOGY AND PATHOPHYSIOLOGY

Genetics

Some hereditary disorders have genes that are associated with cutaneous squamous cell cancer. They include the following:

  • Xeroderma pigmentosum
  • Oculocutaneous albinism
  • Epidermodysplasia verruciformis
  • Genes mutated include TP53, CDKN2A, NOTCH1, Ras, and TP53 (most common gene involved in cutaneous SCC).

RISK FACTORS

  • SCCs arise in:
    • Sun-damaged skin of elderly white individuals of European ancestry
    • Gender (more common in men)
    • Increasing age (average age of onset is the mid-60s)
    • Preexisting lesions of actinic keratosis (AK)
    • UV exposure
    • Preexisting conditions
    • Immunosuppression
      • Solid organ transplantation
      • HIV/AIDS, non-Hodgkin lymphoma, and chronic lymphocytic leukemia have increasing rates of developing cutaneous squamous cell cancer.
  • Chronic skin conditions
    • Burn scars, hidradenitis suppurativa, chronic osteomyelitis, discoid lupus erythematosus, lichen planus, lichen sclerosis et atrophicus
  • Inherited genetic conditions
    • Albinism, epidermolysis bullosa, xeroderma pigmentosum
  • Ionizing radiation exposure
  • Arsenic exposure
  • Ulcers
  • Bowen disease (SCC in situ)
  • Erythroplasia of Queyrat (SCC in situ of the penis)
  • HPV infection (6, 11, 16, 18)
  • Treatment with BRAF inhibitors (vemurafenib and dabrafenib)

GENERAL PREVENTION

  • Protect skin from sun exposure.
  • Wear sunscreen, hats, and UV-protective clothing.
  • Vitamin B3 (nicotinamide) can repair DNA by preventing UV-induced adenosine triphosphate depletion.
  • The U.S. Preventive Services Task Force (USPTF) recommends counseling about minimizing exposure to ultraviolet radiation for people aged 6 months to 24 years with fair skin types to decrease their risk of skin cancer (1).

COMMONLY ASSOCIATED CONDITIONS

AK is the precursor of cutaneous squamous cell cancer, Bowen disease, and erythroplasia of Queyrat.

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