Opioid Use Disorder
BASICS
DESCRIPTION
Opioids are a class of medication that are commonly used for analgesia or pain relief with the concurrent potential for central nervous system depression and/or feelings of euphoria. The diagnosis of opioid use disorder (OUD) refers to the misuse of prescription opioids or the use of illicit opioids, such as heroin that may result in self-harm including death. OUD is considered a chronic illness.
EPIDEMIOLOGY
Prevalence
In 2018, an estimated 10,250,000 people reported opioid misuse (3.7% of population ≥12 years old).
- 2,028,000 of those met the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria for a diagnosis of OUD (0.7% of population ≥12 years old) (1).
RISK FACTORS
- Prior history of substance use disorder
- More severe reported pain
- Co-occurring mental disorders (2)
GENERAL PREVENTION
- Opioid prescriptions have been reduced by 29% between 2006 and 2018, which reduces access to prescription opioids.
- Harm reduction practices can prevent complications from OUD such as clean needle exchanges and safe injection sites.
- Access to intranasal naloxone can prevent opioid-related deaths.
COMMONLY ASSOCIATED CONDITIONS
- Mood disorders
- Personality disorders
- Posttraumatic stress disorder (PTSD)
- Other substance use disorders
- Sexually transmitted infections
- Hepatitis A, B, C
- HIV
- Chronic pain
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Citation
Domino, Frank J., et al., editors. "Opioid Use Disorder." 5-Minute Clinical Consult, 34th ed., Wolters Kluwer, 2026. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688400/all/Opioid_Use_Disorder.
Opioid Use Disorder. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2026. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688400/all/Opioid_Use_Disorder. Accessed July 16, 2025.
Opioid Use Disorder. (2026). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (34th ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688400/all/Opioid_Use_Disorder
Opioid Use Disorder [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2026. [cited 2025 July 16]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688400/all/Opioid_Use_Disorder.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Opioid Use Disorder
ID - 1688400
ED - Domino,Frank J,
ED - Baldor,Robert A,
ED - Golding,Jeremy,
ED - Stephens,Mark B,
BT - 5-Minute Clinical Consult, Updating
UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688400/all/Opioid_Use_Disorder
PB - Wolters Kluwer
ET - 34
DB - Medicine Central
DP - Unbound Medicine
ER -