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Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is a topic covered in the 5-Minute Clinical Consult.

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  • A syndrome of abnormal production of antidiuretic hormone (ADH), despite low serum osmolality, leading to hyponatremia and inappropriately elevated urine osmolality
    • Decreased urinary electrolyte-free water excretion leads to dilutional hyponatremia (total body sodium [Na] levels may be normal or near normal, but the patient’s total body water is increased).
    • Often secondary to medications but may be associated with an underlying disorder, such as neoplasm, pulmonary disorder, or CNS disease
  • Synonym(s): syndrome of inappropriate secretion of ADH; syndrome of inappropriate antidiuresis


  • Often found in the hospital setting, where incidence can be as high as 35%
  • Predominant age: elderly
  • Predominate sex: females > males

Etiology and Pathophysiology

  • Drugs:
    • Antidepressants (e.g., SSRIs, tricyclics, monoamine oxidase inhibitors [MAOIs])
    • Antineoplastic drugs (e.g., vincristine, vinblastine, cisplatin, cyclophosphamide)
    • Antipsychotic agents (e.g., risperidone, quetiapine, phenothiazines, haloperidol)
    • Analgesics (e.g., duloxetine, pregabalin, tramadol, NSAIDs)
    • Anticonvulsants (e.g., carbamazepine, oxcarbazepine, valproic acid, phenytoin)
    • Others (e.g., vasopressin, DDAVP, oxytocin, ciprofloxacin, α-interferon, ecstasy)
  • Malignancies (ectopic ADH production):
    • Bronchogenic carcinoma
    • Lymphoma
    • Mesothelioma
    • Small cell carcinoma of the lung
    • Pancreatic carcinoma
    • Thymoma
  • Pulmonary conditions:
    • Asthma/COPD
    • Atelectasis
    • Cystic fibrosis
    • Positive pressure mechanical ventilation
    • Pneumonia
    • Pulmonary tuberculosis (TB)
    • Sarcoidosis
  • Neurologic causes:
    • Brain tumor
    • CNS injury (i.e., SAH, trauma, stroke)
    • CNS lupus
    • Encephalitis
    • Epilepsy
    • Guillain-Barré syndrome
    • Intracranial surgery
    • Meningitis
    • Multiple sclerosis
  • Other:
    • Acute intermittent porphyria
    • Delirium tremens
    • HIV infection/AIDS
    • Rocky Mountain spotted fever
  • Idiopathic

  • 10% of patients have X-linked mutation of V2R.
  • Polymorphisms in TRPV4 gene

Risk Factors

  • Use of predisposing drugs
  • Advanced age
  • Postoperative status
  • Institutionalization

General Prevention

  • Search for cause, if unknown.
  • Reduce/change medications, if drug induced.
  • Lifelong restriction of fluid intake

Commonly Associated Conditions

See “Etiology and Pathophysiology.”

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Stephens, Mark B., et al., editors. "Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688244/all/Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion__SIADH_.
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688244/all/Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion__SIADH_. Accessed May 22, 2019.
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688244/all/Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion__SIADH_
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 May 22]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688244/all/Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion__SIADH_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) ID - 1688244 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688244/all/Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion__SIADH_ PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -