Description

• An abrupt loss of kidney function, acute kidney injury (AKI) defined as one of the following (1):
  • Increase in serum creatinine (SCr) of ≥0.3 mg/dL within 48 hours; a 50% increase in SCr within 7 days
  • Urine output of <0.5 mL/kg/hr for 6 to 12 hours
• The result is retention of nitrogenous waste, electrolyte, acid–base, and volume abnormalities (1).

Epidemiology

Incidence

• 5% of hospital and 30% of ICU admissions have AKI. 25% of patients develop AKI while in the hospital; 50% of these cases are iatrogenic.
• Developing AKI as an inpatient is associated with >4-fold increased risk of death (2).

Etiology and Pathophysiology

Three categories: prerenal, intrarenal, and postrenal

• Prerenal (reduced renal perfusion, typically reversible):
  • Decreased renal perfusion (often due to hypovolemia) leads to a decrease in glomerular filtration rate (GFR).
  • Caused by hypotension, volume depletion (GI losses, excessive sweating, diuretics, hemorrhage); renal artery stenosis/embolism; burns; heart/liver failure; if decreased perfusion is prolonged or severe, it can progress to ischemic acute tubular necrosis (ATN)
• Intrarenal (intrinsic kidney injury, often from prolonged or severe renal hypoperfusion)
  • ATN—from prolonged prerenal azotemia, radiographic contrast material, aminoglycosides, nonsteroidal anti-inflammatory drugs (NSAIDs), or other nephrotoxic substances
  • Glomerulonephritis (GN)
  • Acute interstitial nephritis (AIN; drug induced), arteriolar insults, vasculitis, accelerated hypertension, cholesterol embolization (following an intra-arterial procedure), intrarenal deposition/sludging (uric acid nephropathy and multiple myeloma [Bence Jones proteins])
• Postrenal (obstruction of the collecting system)
  • Extrinsic compression (e.g., benign prostatic hypertrophy [BPH], carcinoma, pregnancy); intrinsic obstruction (e.g., calculus, tumor, clot, stricture, sloughed papillae); decreased function (e.g., neurogenic bladder), leading to obstruction of the urinary collection system

Genetics
No known genetic pattern

Risk Factors

• Chronic kidney disease (CKD); comorbid conditions (e.g., diabetes mellitus, hypertension, heart failure, liver failure); advanced age; radiocontrast material exposure (intravascular)
• Medications that impair autoregulation of GFR (NSAIDs, angiotensin converting enzyme inhibitors [ACEI], angiotensin II receptor blockers [ARB], cyclosporine/tacrolimus)
• Nephrotoxic medications (e.g., aminoglycoside antibiotics, platinum-based chemotherapy); hypovolemia (e.g., diuretics, hemorrhage, GI losses); sepsis, surgery, rhabdomyolysis; solitary kidney (risk in nephrolithiasis); BPH; malignancy (e.g., multiple myeloma)

General Prevention

• Maintain adequate renal perfusion with isotonic fluids, vasopressor support if necessary.
• Avoid nephrotoxic agents including (but not limited to) known nephrotoxic medications, herbal supplements, IV contrast.

Commonly Associated Conditions

Hyperkalemia, hyperphosphatemia, hypercalcemia, hyperuricemia, hydronephrosis, BPH, nephrolithiasis, congestive heart failure (CHF), uremic pericarditis, cirrhosis, CKD, malignant hypertension, vasculitis, drug reactions, sepsis, severe trauma, burns, transfusion reactions, recent chemotherapy, rhabdomyolysis, internal bleeding, dehydration

History

• Thorough medication history; changes in oral intake, urine output, and body weight
• Prerenal: thirst, orthostatic symptoms, vomiting, diarrhea, bleeding
• Intrarenal: nephrotoxic medications, radiocontrast material, other toxins
• Postrenal: colicky flank pain that radiates to the groin suggests ureteric obstruction such as a stone; nocturia, frequency, and hesitancy suggest prostatic disease; suprapubic and flank pain are usually secondary to distension of the bladder and collecting system; anticholinergic drugs inhibit bladder emptying.
• Uremic symptoms: lethargy, nausea/vomiting, anorexia, pruritus, restless legs, sleep disturbance, hiccups
• Livedo reticularis, SC nodules, and ischemic digits despite good pulses suggest atheroembolization.
• Flank pain may suggest renal artery or vein occlusion.

Physical Exam

• Uremic signs: altered sensorium, seizures, asterixis, myoclonus, pericardial friction rub, peripheral neuropathies
• Prerenal signs: tachycardia, decreased jugular venous pressure (JVP), orthostatic hypotension, dry mucous membranes, decreased skin turgor; comorbid stigmata of sepsis, liver disease, or heart failure
• Intrinsic renal signs: pruritic rash, livedo reticularis, SC nodules, ischemic digits despite good pulses
• Postrenal signs: suprapubic distension, flank pain, enlarged prostate

Diagnostic Tests & Interpretation

Initial Tests (lab, imaging)

• Compare to baseline renal function (creatinine [Cr] and GFR) (1)[A]
• Urinalysis: dipstick for blood and protein; microscopy for cells, casts, and crystals (1)[A]
• Sterile pyuria (especially WBC casts) suggests AIN; triad of fever, rash, and eosinophilia present in 10% of cases.
• Proteinuria, hematuria, and edema, often with nephritic urine sediment (RBCs and RBC casts), suggest GN or vasculitis.
• Casts: transparent hyaline casts—prerenal etiology; pigmented granular/muddy brown casts—ATN; WBC casts—AIN; RBC casts—GN
• Urine eosinophils: ≥1% eosinophils suggest AIN (poor sensitivity).
• Urine electrolytes in an oliguric state
  • FE_Na = [(Urine Na × serum Cr)/(serum Na 3 Urine Cr_r)]
  • FE_Na <1% suggests prerenal etiology and >2% indicates intrinsic cause
  • If patient on diuretics, use FE_urea instead of FE_Na. FE_urea = [(U_urea × P_Cr) / (P_BUN × U_Cr)] × 100; FE_urea <35% suggests prerenal etiology.
• CBC, BUN, SCr, electrolytes (including Ca/Mg/P); consider arterial or venous blood gas (ABG/VBG).
• Common lab abnormalities in AKI
  • Increased: potassium, phosphate, magnesium, uric acid
  • Decreased: hemoglobin, calcium
• Calculate Cr clearance (CrCl) to ensure appropriate medication dosing.
• Imaging:
  • Renal ultrasound (US): first line; excludes postrenal causes; identifies kidney size, nephrolithiasis
  • Doppler-flow renal US: evaluates for renal artery stenosis/thrombosis; operator dependent
  • Abdominal x-ray (kidney, ureter, bladder [KUB]): identifies calcification, renal calculi, kidney size
• Novel biomarkers such as urinary IL-18, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), plasma cystatin C, TIMP-2, and IGFBP7 under investigation (3)

Follow-Up Tests & Special Considerations

• Consider CK (rhabdomyolysis) and immunologic testing (if GN or vasculitis suspected).
• Advanced imaging if initial tests unrevealing
  • Prerenal: US as effective as CT for obstruction; noncontrast helical CT: most sensitive test for nephrolithiasis
  • Radionuclide renal scan: evaluates renal perfusion, function (GFR), and presence of obstructive uropathy and extravasation. MRI: acute tubulointerstitial nephritis with increased T2-weighted signal; gadolinium contrast is contraindicated if GFR <30 mL/min.

Diagnostic Procedures/Other
Cystoscopy with retrograde pyelogram evaluates for bladder tumor, hydronephrosis, obstruction, and upper tract abnormalities without risk of contrast nephropathy.

Test Interpretation
Kidney biopsy: last resort if patient does not respond to therapy or if diagnosis remains unclear; most useful to evaluate intrinsic AKI of unclear cause (AIN, GN, vasculitis, or renal transplant rejection)

General Measures

• Identify and correct prerenal and postrenal causes; stop nephrotoxic drugs and renally dose others. Strictly monitor intake/output and daily weight; optimize cardiac output to maintain renal perfusion. Optimize nutrition and treat any infections.
• Indications for RRT: volume overload, severe hyperkalemia, or metabolic acidosis refractory to medical management; advanced uremic complications (pericarditis, encephalopathy, bleeding diathesis); pulmonary edema

Medication

First Line

• Find and treat the underlying cause.
• Prevent fluid overload, and correct electrolyte imbalances—particularly hyperkalemia.
  • If patient is oliguric and not volume overloaded, a monitored fluid challenge may help.
• Furosemide is ineffective in preventing and treating AKI but can (judiciously) be used to manage volume overload and/or hyperkalemia. Furosemide stress test may predict the likelihood of progressive AKI, need for RRT, and mortality.
• Dopamine, natriuretic peptides, insulin-like growth factor, and thyroxine have no benefit in the treatment of AKI.
• Fenoldopam, a dopamine agonist, has been equivocal in decreasing risk of RRT and mortality in AKI; not currently recommended (1)[C]
• Hyperkalemia with ECG changes: Give IV calcium gluconate, isotonic sodium bicarbonate (only if acidemic, and avoid use of hypertonic “amps” of NaHCO₃), glucose with insulin, and/or high-dose nebulized albuterol (to drive K⁺ into cells); Kayexalate and/or furosemide (to increase K⁺ excretion); hemodialysis if severe/refractory
• Fluid restriction may be required for oliguric patients to prevent worsening hyponatremia.
• Effective strategies for AKI prevention: isotonic IVF, once-daily dosing of aminoglycosides; use of lipid formulations of amphotericin B, use of iso-osmolar nonionic contrast media
• Risk of contrast-induced AKI is reduced by avoidance of hypovolemia: isotonic saline 1 mL/kg/hr morning of procedure and continued until next morning or isotonic NaHCO₃ × mL/kg/hr × 1 hour before and 1 mL/kg/hr × 6 hours after contrast administration; N-acetylcysteine not of benefit

Second Line

• Tamsulosin or other selective α-blockers for bladder outlet obstruction secondary to BPH
• Dihydropyridine calcium channel blockers may have a protective effect in posttransplant ATN.

Issues For Referral

• Consider nephrology consultation for potential initiation of RRT; persistent and prolonged anuria or oliguria; refractory elevation in BUN and/or Cr despite appropriate fluid and/or electrolyte replacement; underlying structural or functional renal disease (e.g., glomerulonephropathies, SLE nephritis, cryoglobulinemia); renal transplant patients
• Consider urology consult for obstructive nephropathy.

Surgery/Other Procedures

• Relieve obstruction by retrograde ureteral catheters/percutaneous nephrostomy.
• Hemodialysis catheter placement

Complementary and Alternative Medicine

Many herbal and dietary supplements are potentially nephrotoxic (aristolochic acid, ochratoxin A, djenkol bean, impila, orellanine, cat’s claw). Obtain a thorough medication history from the patient.

Admission, Inpatient, and Nursing Considerations

• Treat life-threatening complications: hyperkalemia, metabolic acidosis, volume overload, and advanced uremia
• If hypovolemic, give isotonic IV fluids. Monitor fluid balance and daily weights.
• Consider urinary catheter placement to quantify urine output, weighing risks of catheter associated urinary tract infection (CAUTI). Remove as soon as possible. Stabilize renal function and ensure treatment plan prior to discharge; dialysis if necessary

Follow-up Recommendations

Nephrology follow-up if persistent renal impairment and/or proteinuria

Diet

• Total caloric intake of 20 to 30 kcal/kg/day (1)
• Restrict Na⁺ to 2 g/day (unless hypovolemic); consider K⁺ restriction (2 to 3 g/day) if hyperkalemic. If hyperphosphatemic, consider use of phosphate binders, although no evidence of benefit in AKI. Avoid magnesium- and aluminum-containing compounds.

Patient Education

• Keep well-hydrated. Avoid nephrotoxic drugs, such as NSAIDs and aminoglycosides.
• Acute Kidney Injury (AKI). National Kidney Foundation: https://www.kidney.org/atoz/content/AcuteKidneyInjury

Prognosis

• Depending on the cause, comorbid conditions, and age of patient, mortality ranges from 5% to 80%.
• In cases of prerenal and postrenal AKI, short duration of AKI correlates with good rates of recovery. Intrarenal etiologies take longer to recover. Even with complete recovery from AKI, affected patients are at higher subsequent risk of developing CKD and ESRD.
• Among patients who require RRT for AKI, recovery more likely with higher baseline eGFR, AKI from ATN due to sepsis or surgery; recovery less likely with preexisting heart failure

Complications

Death, sepsis, infection, seizures, paralysis, peripheral edema, CHF, arrhythmias, uremic pericarditis, bleeding, hypotension, anemia, hyperkalemia, uremia

See Also

• Chronic Kidney Disease ; Glomerulonephritis, Acute ; Hepatorenal Syndrome ; Hyperkalemia ; Prostatic Hyperplasia, Benign (BPH) ; Reye Syndrome ; Rhabdomyolysis ; Sepsis
• Algorithm: Anuria or Oliguria

ICD-10

• N17 Acute kidney failure
• N17.0 Acute kidney failure with tubular necrosis
• N17.1 Acute kidney failure with acute cortical necrosis
• N17.2 Acute kidney failure with medullary necrosis
• N17.8 Other acute kidney failure
• N17.9 Acute kidney failure, unspecified

SNOMED

• 140031000119103 Acute nontraumatic kidney injury
• 14669001 Acute renal failure syndrome
• 236428007 Nephrotoxic acute renal failure
• 236429004 Acute drug-induced renal failure
• 430535006 Acute renal failure with oliguria
• 58574008 Acute nephropathy