Eosinophilic Esophagitis

Eosinophilic Esophagitis is a topic covered in the 5-Minute Clinical Consult.

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Basics

A chronic, immune-mediated, inflammatory esophageal disease characterized clinically in adults by dysphagia, food impaction, and heartburn and in children with nonspecific abdominal complaints, abdominal pain, and failure to thrive. Histologically, EoE is characterized by an eosinophilic predominate inflammation (1)[A].

Epidemiology

All ages, most common in 20s to 30s; male > female, 3:1

Incidence
Incidence in general population is ~1/10,000 per year.

Prevalence

Gradually increasing, perhaps due to better case finding; 45 to 55/100,000

  • Increased prevalence in those with celiac disease

Etiology and Pathophysiology

  • An atopic inflammatory disease; pathogenesis is an aberrant immune response to antigenic stimulation.
  • Like eczema and asthma, T-helper 2 (TH2) lymphocytes play a role, as do mixed IgE and non–IgE-mediated allergic responses to food and environmental allergens.
  • Although not well-understood, the pathophysiology of EoE is postulated to be due to increased recruitment and activation of eosinophils in the esophagus by the eosinophil chemoattractants eotaxin-3, IL-5, and IL-13, which are ultimately responsible for the inflammation and fibrotic changes seen.

Genetics
  • EoE susceptibility may be caused by polymorphisms in thymic stromal lymphopoietin protein (TSLP).
  • Potential new subphenotype of EoE (may also overlap with GERD): proton pump inhibitor (PPI)–responsive esophageal eosinophilia (REE), where PPIs may act to decrease the inflammatory response in EoE

Risk Factors

  • EoE is associated with atopy/allergic disorders, such as asthma, hay fever, or eczema (1)[A].
  • High rate of associated food and aero antigen allergies/anaphylaxis

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Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Eosinophilic Esophagitis ID - 117528 ED - Baldor,Robert A, ED - Domino,Frank J, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117528/all/Eosinophilic_Esophagitis PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -