Glaucoma, Primary Open-Angle



Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy which causes loss of the optic nerve rim and retinal nerve fiber layer (RNFL) with associated visual field defects. POAG is associated with increased intraocular pressure (IOP). Normal IOP is 10 to 21 mm Hg. Glaucoma can be present even with normal IOP.

Pregnancy Considerations
Prostaglandins should be avoided during pregnancy in the treatment of POAG.


Prevalence in persons >40 years of age is ~1.8%.

Etiology and Pathophysiology

  • Aqueous humor is produced by the ciliary epithelium of the ciliary body and is secreted into the posterior chamber of the eye. Aqueous humor then flows through the pupil and enters the anterior chamber to be drained by the trabecular meshwork (TM) in the iridocorneal angle of the eye. It then drains into the Schlemm canal and passes into the episcleral venous system. 5–10% of the total aqueous humor outflow leaves via the uveoscleral pathway.
  • Impaired aqueous humor outflow through the TM leads to greater resistance in the aqueous humor drainage system and causes an increase in IOP.


  • TMCO1 genotype has been found to increase the risk of developing glaucoma among non-Hispanic whites.
  • The myocilin (MYOC) gene was the first gene associated with POAG.

Risk Factors

  • Myopia
  • Diabetes mellitus (DM)
  • African descent
  • Hypothyroidism
  • Positive family history
  • Prolonged use of topical, periocular, inhaled, or systemic corticosteroids
  • Systemic calcium-channel blockers
  • High coffee consumption
  • Prior history pars plana vitrectomy
  • Obstructive sleep apnea
  • Hypertension

General Prevention

Higher dietary nitrate and green leafy vegetable intake has been associated with a lower POAG risk. Evidence suggests that nitrate, a precursor of nitric oxide, is beneficial for blood circulation.

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