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Tarsal Tunnel Syndrome

Tarsal Tunnel Syndrome is a topic covered in the 5-Minute Clinical Consult.

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Tarsal tunnel syndrome occurs when there is compression neuropathy of the posterior tibial nerve as it passes behind the medial malleolus and under the flexor retinaculum (laciniate ligament) in the medial ankle (the tarsal tunnel).


  • Women are slightly more affected than men (56%).
  • All postpubescent ages are affected.

Etiology and Pathophysiology

  • Contents within the tarsal tunnel from the anterior medial to the posterior lateral side include the following: the posterior tibial tendon, the flexor digitorum longus tendon, the posterior tibial artery and veins, the posterior tibial nerve, and the flexor hallucis tendon.
  • The posterior tibial nerve passes through the tarsal tunnel, which is formed by three osseus structures—sustentaculum tali, medial calcaneus, and medial malleolus—covered by the laciniate ligament.
  • Compression of the posterior tibial nerve within the tarsal tunnel results in decreased blood flow, ischemic damage, and resultant symptoms (1).
  • Chronic compression can destroy endoneurial microvasculature, leading to edema and (eventually) fibrosis and demyelination (2).
  • Increased pressure in the tarsal tunnel is caused by a variety of mechanical and biochemical mechanisms. The specific cause for compression is identifiable in only 60–80% of patients (1).
  • Three general categories: trauma, space-occupying lesions, deformity (1)
    • Trauma including displaced fractures, deltoid ligament sprains, or tenosynovitis
    • Varicosities
    • Hindfoot varus or valgus
    • Fibrosis of the perineurium
  • Other causes:
    • Osseous prominences
    • Ganglia; lipoma; neurilemmoma
    • Inflammatory synovitis
    • Pigmented villonodular synovitis
    • Tarsal coalition
    • Accessory musculature
  • In patients with systemic disease (e.g., diabetes), the “double crush” syndrome refers to the development of a second compression along the same nerve at a site of anatomic narrowing in patients with previous proximal nerve damage (3).

Risk Factors

  • Tarsal tunnel syndrome is associated with certain occupations and activities involving repetitive weight bearing on the foot and ankle (jogging, dancing).
  • Other possible risk factors include (4):
    • Diabetes
    • Systemic inflammatory arthritis
    • Connective tissue disorders
    • Obesity
    • Varicosities
    • Heel varus or valgus
    • Bifurcation of the posterior tibial nerve into medial and lateral plantar nerves proximal to the tarsal tunnel

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Stephens, Mark B., et al., editors. "Tarsal Tunnel Syndrome." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117110/all/Tarsal_Tunnel_Syndrome.
Tarsal Tunnel Syndrome. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117110/all/Tarsal_Tunnel_Syndrome. Accessed April 20, 2019.
Tarsal Tunnel Syndrome. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117110/all/Tarsal_Tunnel_Syndrome
Tarsal Tunnel Syndrome [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 20]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117110/all/Tarsal_Tunnel_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Tarsal Tunnel Syndrome ID - 117110 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/117110/all/Tarsal_Tunnel_Syndrome PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -