Cushing Disease and Cushing Syndrome
Basics
Description
- Cushing syndrome is defined as excessive glucocorticoid exposure from exogenous (steroid medications) or less commonly from endogenous sources (pituitary, adrenal, pulmonary, etc.).
- Cushing disease is glucocorticoid excess due to excessive adrenocorticotropic hormone (ACTH) secretion from a pituitary tumor.
- System(s) affected: endocrine/metabolic, musculoskeletal, skin/exocrine, cardiovascular; neuropsychiatric
Pediatric Considerations
- Rare in infancy and childhood
- The most common presenting symptom is lack of growth and weight gain.
Pregnancy Considerations
Pregnancy may exacerbate the disease.
Epidemiology
Prevalence
- An estimated 10 to 15 cases per million people are affected yearly.
- Cushing disease most commonly affects adults aged 20 to 50 years and females.
- 2–5% prevalence reported in difficult-to-control diabetics with obesity and hypertension (HTN)
Etiology and Pathophysiology
- Cortisol is a steroid hormone produced by the zona fasciculata of the adrenal cortex. It is classically a catabolic hormone released during periods of stress. The excess causes increased free glucose, insulin resistance, and protein catabolism.
- Prolonged glucocorticoid use such as in asthma and chronic obstructive pulmonary disease is the most common exogenous source.
- Endogenous cause is either ACTH-dependent or ACTH-independent, as
- ACTH is typically secreted by the pituitary which stimulates adrenal release. As such, release of ACTH from any source will result in increased cortisol level.
Genetics
- Multiple endocrine neoplasia (MEN)
- McCune-Albright syndrome (mutation of GNAS1 gene)
Risk Factors
Prolonged use of corticosteroids
General Prevention
Avoid corticosteroid exposure.
Commonly Associated Conditions
Psychiatric disorders, diabetes, HTN, hypokalemia, infections, dyslipidemia, osteoporosis, and poor physical fitness
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Citation
Domino, Frank J., et al., editors. "Cushing Disease and Cushing Syndrome." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2020. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116961/all/Cushing_Disease_and_Cushing_Syndrome.
Cushing Disease and Cushing Syndrome. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2020. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116961/all/Cushing_Disease_and_Cushing_Syndrome. Accessed December 2, 2023.
Cushing Disease and Cushing Syndrome. (2020). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (27th ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116961/all/Cushing_Disease_and_Cushing_Syndrome
Cushing Disease and Cushing Syndrome [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2020. [cited 2023 December 02]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116961/all/Cushing_Disease_and_Cushing_Syndrome.
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