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Retinopathy of Prematurity

Retinopathy of Prematurity is a topic covered in the 5-Minute Clinical Consult.

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Basics

Description

  • Proliferative disorder of the retinal blood vessels in premature infants: The normal retinal vascularization occurs nasally at ~36 weeks’ gestational age and temporally at ~40 weeks’ gestational age.
  • System(s) affected: nervous
  • Synonym(s): ROP; retrolental fibroplasia

Epidemiology

Incidence
  • 65.8% of infants weighing <1,251 g at birth and 81.6% of those weighing <1,000 g
  • Predominant age: premature infants
  • Predominant sex: male = female

Etiology and Pathophysiology

Oxidative processes (influenced by high levels of arterial oxygen) in immature retina may be an important causative factor.

Genetics
African American infants appear less susceptible.

Risk Factors

  • Low birth weight
  • Poor postnatal weight gain
  • Prematurity
  • Supplemental oxygen; once the retina becomes fully vascularized, oxygen does not affect the retina.
  • Supplemental oxygen given to premature infants with moderate ROP will not make the retinopathy worse.
  • Maternal diabetes is associated with the development of ROP in premature infants with a birth weight of 1,500 g or more.

Commonly Associated Conditions

Neonatal respiratory distress syndrome

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Citation

Stephens, Mark B., et al., editors. "Retinopathy of Prematurity." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116905/all/Retinopathy_of_Prematurity.
Retinopathy of Prematurity. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116905/all/Retinopathy_of_Prematurity. Accessed April 24, 2019.
Retinopathy of Prematurity. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116905/all/Retinopathy_of_Prematurity
Retinopathy of Prematurity [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 24]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116905/all/Retinopathy_of_Prematurity.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Retinopathy of Prematurity ID - 116905 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116905/all/Retinopathy_of_Prematurity PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -