Priapism
Basics
Description
- Penile (or less common clitoral) erection lasting for >4 hours and unrelated to sexual stimulation or arousal
- Classification:
- Ischemic (low-flow, veno-occlusive): accounts for 95% of priapism cases. It is associated with ischaemia of the corpora cavernosa.
- Nonischemic (high-flow, arterial): less common and often painless and does not require urgent treatment
- Recurrent ischemic (“stuttering”) priapism: episodic, short-lived, and may not require intervention
- Malignant priapism: rare, resulting most commonly from penile metastases related to primary bladder, prostatic, rectosigmoid, and renal tumors
- System(s) affected: reproductive and vascular
- Functional impairment: neurophysiologic, sexual, psychosocial
Pediatric Considerations
In children, the most common etiology is sickle cell disease (SCD) (63% of cases). Less common etiologies, occurring more typically in the adolescent years, are leukemia, idiopathic, penile trauma (e.g., post circumcision), or illicit drugs (up to 35% of cases).
Epidemiology
Incidence
- About 5.3 per 100,000 men per year
- Age: There has been an age shift since 2008 toward men in their 40s. The incidence doubles in men aged >40 years (2.9 vs. 1.5/100,000 person-years).
- Race: 61.1% African American (correlated with incidence of SCD), 30% Caucasian, 6.3% Hispanic
Etiology and Pathophysiology
- Anatomy and physiology:
- The penis consists of three longitudinally oriented corpora: two dorsolaterally paired corpora cavernosa that are responsible for penile erection and a single ventral corpus spongiosum that surrounds the glans penis and extends distally to form the glans penis.
- In general, the penile artery supplies the penis. It divides into three branches: dorsal artery, bulbar artery (supplies the corpus spongiosum), and cavernosal artery (the main blood supply to the erectile tissue).
- In ischemic priapism, decreased venous outflow results in increased intracavernosal pressure. This leads to erection, decreased arterial inflow, blood stasis, local hypoxia, and acidosis (a compartment syndrome). Penile tissue necrosis and fibrosis may occur if priapism persists >24 hours. Pathophysiology mechanisms thought to contribute to impaired smooth muscle relaxation and decreased venous outflow include dysregulation of the NO/cGMP, RhoA/Rho kinase, and opiorphin signaling pathways as well as excessive adenosine signaling (1).
- In nonischemic priapism, increased arterial flow without decreased venous outflow results in a sustained, nonpainful, partially rigid erection.
- Causes:
- Ischemic priapism:
- Idiopathic: about 50% cases
- Hematologic dyscrasias: SCD, thalassemia, leukemia, multiple myeloma, fat emboli during hyperalimentation, hemodialysis, glucose-6-phosphate dehydrogenase (G6PD) deficiency, factor V Leiden mutation
- Infections (toxin mediated): urinary tract infections, scorpion sting, spider bite, rabies, malaria
- Metabolic disorders: nephrolithiasis, amyloidosis, Fabry disease, gout
- Neurogenic disorders: syphilis, spinal cord injury, cauda equina syndrome, autonomic neuropathy, lumbar disc herniation, spinal stenosis, cerebrovascular accident, brain tumor, spinal anesthesia
- Neoplasms: penis, urethra, bladder, prostate, kidney and rectum
- Medications:
- Vasoactive erectile agents (i.e., papaverine, phentolamine, prostaglandin E1/alprostadil)
- α-Adrenergic receptor antagonists (i.e., prazosin, terazosin, doxazosin, tamsulosin)
- Antidepressants and antipsychotics (i.e., trazodone, bupropion, fluoxetine, sertraline, lithium, clozapine, risperidone, olanzapine, chlorpromazine, thioridazine, phenothiazines)
- Antihypertensives (i.e., hydralazine, guanethidine, propranolol)
- Hormones (i.e., gonadotropin-releasing hormone, testosterone)
- Anxiolytics (hydroxyzine)
- Anticoagulants (heparin, warfarin)
- Recreational drugs (i.e., alcohol, marijuana, cocaine)
- Nonischemic priapism (2):
- Almost universally associated with penile or perineal trauma resulting in a fistula between the cavernous artery and the corpus cavernosum
- Acute spinal cord injury
- Treatment of ischemic priapism
- Ischemic priapism:
Risk Factors
- SCD has a lifetime risk of ischemic priapism 29–42%.
- Dehydration correlated with SCD or trait
- Prior history of priapismic episodes
General Prevention
- Avoid dehydration (SCD cases).
- Avoid excessive sexual stimulation.
- Avoid or limit causative drugs.
- Avoid trauma to the genital area
Commonly Associated Conditions
- SCD (42.9%) or sickle cell trait (2.5%)
- Drug abuse (7.9%)
- G6PD deficiency
- Leukemia
- Neoplasm
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Citation
Domino, Frank J., et al., editors. "Priapism." 5-Minute Clinical Consult, 33rd ed., Wolters Kluwer, 2025. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116486/all/Priapism.
Priapism. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2025. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116486/all/Priapism. Accessed December 12, 2024.
Priapism. (2025). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical Consult (33rd ed.). Wolters Kluwer. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116486/all/Priapism
Priapism [Internet]. In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2025. [cited 2024 December 12]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116486/all/Priapism.
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