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Mitral Stenosis

Mitral Stenosis is a topic covered in the 5-Minute Clinical Consult.

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  • The mitral valve apparatus is made up of anterior and posterior leaflets which are attached to the anterolateral and posteromedial papillary muscles via the chordae.
  • Mitral stenosis (MS) is a narrowing of the valve area causing obstruction of the left ventricular inflow, resulting in increased left atrial pressures and consequent elevation of pulmonary venous and atrial pressures.
  • Staging of the disease is used to guide appropriate treatment regimen. Stages vary from A (with risk factors), B (hemodynamic obstruction), C (severe but no symptoms), to D (symptomatic) (1).
  • The most common etiology for MS is rheumatic heart disease (RHD), and MS is the most common valvular disease secondary to RHD.


  • Globally, the prevalence of RHD is 15.6 million every year. Approximately 282,500 new cases are reported and 233,000 deaths have been attributed to RHD.
  • Predominant age: Symptoms primarily occur in 3rd to 4th decades; predominant sex: female > male (3:1)

Incidence of rheumatic disease in the continental United States remains very low. Annual incidence of acute rheumatic fever in the continental United States is 0.04 to 0.06 cases per 1,000 children. However, global burden remains significant (2).

Etiology and Pathophysiology

  • Narrowing of the valve orifice leads to obstruction of blood flow between LA and LV. This impairs LV filling during diastole and causes increased LA pressure. Increased LA pressure is transmitted passively (“back pressure”) to the pulmonary circulation causing pulmonary hypertension and pulmonary congestion over time.
  • Chronic LA pressure overload results in atrial dilation and fibrosis and may cause Afib.
  • Rheumatic fever: most common etiology (see “Risk Factors”)
  • Pathognomonic commissural fusion, leaflet thickening and “fish mouth appearance” seen with RHD
  • Aging (extension of mitral annular calcification)
  • Rare causes: congenital (associated with mucopolysaccharidoses), autoimmune: systemic lupus erythematosus (SLE); rheumatoid arthritis; malignant carcinoid; Whipple disease; methysergide therapy; and other acquired pathologies such as LA myxoma, LA thrombus, endomyocardial fibrosis

Risk Factors

  • Rheumatic fever is the greatest risk factor.
    • 30–40% of rheumatic fever patients eventually develop MS, presenting 20 years after diagnosis of rheumatic fever.
    • Acute rheumatic fever occurs 2 to 3 weeks after an episode of untreated pharyngitis caused by rheumatogenic group A streptococci (GAS) organism in a genetically susceptible host.
    • Recurrent infections can accelerate the progression of the disease.
    • Low socioeconomic status (i.e., crowded conditions) favors the spread of streptococcal infection.
  • Aging (increasing valvular calcification)
  • Chest irradiation (increasing tissue fibrosis)

General Prevention

  • Prompt recognition and treatment of GAS infection; recognition of cardinal signs and symptoms of acute rheumatic fever via Jones criteria
  • Ultrasound-based screening has been shown to increase diagnosis of RHD in asymptomatic patients residing in areas of high prevalence.

Commonly Associated Conditions

  • Afib (30–40% of symptomatic patients)
  • Associated valve lesions due to chronic inflammation (aortic stenosis, aortic insufficiency)
  • Pulmonary HTN and right heart failure
  • Systemic embolism, stroke, pulmonary embolism (10%)
  • Infection, including infectious endocarditis (1–5%)
  • Chronic rheumatic myocarditis

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Stephens, Mark B., et al., editors. "Mitral Stenosis." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116385/all/Mitral_Stenosis.
Mitral Stenosis. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116385/all/Mitral_Stenosis. Accessed April 18, 2019.
Mitral Stenosis. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116385/all/Mitral_Stenosis
Mitral Stenosis [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 18]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116385/all/Mitral_Stenosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Mitral Stenosis ID - 116385 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116385/all/Mitral_Stenosis PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -