Description

• Clinical manifestations of mastoiditis typically appear days to weeks after the first middle ear symptoms.
• Subdivided according to pathologic stage:
  • Acute mastoiditis with periostitis (incipient mastoiditis): purulent material in the mastoid cavities; symptom duration typically ≤1 month
  • Coalescent mastoiditis (acute mastoid osteitis): destruction of the thin bony septae between air cells; followed by the formation of abscess cavities with pus dissecting into adjacent areas
• Masked mastoiditis (subacute mastoiditis): low grade, persistent infection with destruction of the bony septae between air cells; occurs in patients with persistent middle ear effusion or recurrent episodes of inadequately treated AOM
• Chronic mastoiditis: associated with failed treatment of chronic otitis media; often associated with cholesteatoma; symptoms last for months to years.

Epidemiology

Highest incidence in children aged <2 years

• Similar to population susceptible to AOM (male, daycare attendance)
• Less common if immunizations up-to-date and antibiotics used to treat suppurative AOM

Incidence
1.2 to 3.8 cases per 100,000 children per year in the United States (1)

Etiology and Pathophysiology

• Subclinical stage begins with AOM and inflammation of mastoid air cells.
• Mastoid is part of petrous temporal bone composed of air-filled cells.
• Mastoid aditus and antrum form a narrow connection between middle ear and mastoid air cells.
  • Fluid in the middle ear can cause obstruction at aditus or antrum, blocking outflow tract of mastoid air cells.
  • Edema and accumulation of purulent material most commonly spreads from mastoid air cells to periosteum via mastoid emissary veins with penetration of periosteum (acute mastoiditis with periosteitis).
• Increased pressure from fluid within the air cells leads to destruction of bony septae (acute mastoid osteitis/acute coalescent mastoiditis).
• Acute mastoid osteitis can spread to adjacent areas in head and neck with abscess formation:
  • Subperiosteal abscess (most common complication), Bezold abscess, suppurative labyrinthitis, suppurative CNS complications (2)
• AOM: Streptococcus pneumoniae, nontypeable Haemophilus influenzae
• Acute mastoiditis: S. pneumoniae (most common), group A streptococci—Streptococcus pyogenes, Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), H. influenzae, Fusobacterium necrophorum
• Chronic mastoiditis: Pseudomonas aeruginosa, S. aureus, anaerobic bacteria, polymicrobials (organisms present in external ear canal), rarely Mycobacterium tuberculosis
• Abscess: S. aureus, mycobacteria, Aspergillus
• Increased incidence of penicillin-resistant S. pneumoniae infections has gradually lead to higher incidence of mastoiditis as complication of AOM.

Genetics
No known genetic pattern

Risk Factors

• Cholesteatoma appears as squamous pearl in anterosuperior area of middle ear near tympanic membrane.
• Recurrent AOM or chronic suppurative otitis media
• Immunocompromised state

General Prevention

• Ensure immunizations (particularly pneumococcal vaccine) are up-to-date.
• Referral to ENT for chronic otitis media
• Appropriate diagnosis and treatment of AOM; prevent recurrent AOM.
  • Chemoprophylaxis for AOM is controversial. Historically, consider in children with two episodes of AOM in first 6 months of life or in older children, three episodes in 6 months, or four episodes in 1 year. Chemoprophylaxis is not currently recommended by American Academy of Pediatrics due to concern for multidrug resistance.
• Wear ear plugs when swimming or showering to keep water out of the ears with AOM.
• Treat chronic eustachian tube dysfunction (pressure equalization tubes).
• Early diagnosis of cholesteatoma

Commonly Associated Conditions

AOM