Germ Cell Tumors
Germ cell tumors (GCTs) are a heterogeneous group with a suspected common cell of origin, the primordial germ cell.
- Their location can be gonadal or extragonadal.
- The numerous histologic subtypes are broadly classified as mature or immature teratomas and malignant GCTs.
- See “Brain Tumor” chapter for primary CNS GCT.
The incidence has a bimodal distribution with a smaller peak in early infancy and a larger peak in adolescence.
- In children younger than 15 years of age, GCTs occur at a rate of 2.4 cases per million children, and they account for 2–3% of all malignancies.
- Between 15 and 19 years of age, extracranial GCTs account for approximately 14% of cancer diagnoses.
- Teratomas and germinomas are the predominant histologic subtypes of early infancy and adolescence respectively.
- Sacrococcygeal teratomas account for 50% of childhood teratomas. They are most prevalent in infants (1:40,000 live births); with a female predominance (4:1)
- Sex chromosome abnormalities are associated with an increased risk for GCTs.
- Klinefelter syndrome is associated with an increased risk of mediastinal GCTs.
- Approximately 50% of adolescent mediastinal GCTs are associated with a cytogenetic diagnosis of Klinefelter syndrome.
- Turner syndrome with any portion of Y chromosome material, Swyer syndrome, nonscrotal partial androgen insensitivity, Frasier syndrome, and males with Denys-Drash syndrome are all associated with streak gonads at increased risk for developing GCTs.
- History of cryptorchidism is associated with an increased risk of testicular GCT.
Familial GCT has been described in 1.5–2% of adult GCTs and a similar contribution to adolescent GCTs is presumed.
- Prophylactic gonadectomy is recommended for streak gonads in the specific syndromes mentioned above because of the increased risk of developing GCTs.
- Guidelines on the management of cryptorchidism recommend the following to decrease the future risk of testicular GCT:
- Orchidopexy by 18 months of age
- Consideration of orchiectomy of an undescended testis in all boys with a normal contralateral testis when orchidopexy is not feasible
- Consider orchiectomy or biopsy in a post pubertal boy with cryptorchidism.
- Counsel all men with a history of cryptorchidism and/or their parents regarding the long-term risk of testicular cancer.
- GCTs are hypothesized to originate from primordial germ cells containing neoplastic genetic aberrations.
- Arrested migration of primordial germ cells is presumed to explain the midline location of extragonadal GCTs.
- The postpubertal peak in the incidence of GCTs suggests hormonal factors are involved in their growth.
- Isochromosome 12p or i(12)p is present in more than 80% of postpubertal GCTs. GCTs without the i(12)p typically have gain of 12p chromosomal material.
- Mature and immature ovarian tumors are biologically distinct in their lack of association with the i(12)p.
- A number of other genetic mutations have been observed in testicular GCTs.
- Malignant GCTs in children younger than age 4 years typically contain cytogenetic abnormalities of chromosomes 1, 3, 6, and others.
- The i(12)p is rarely seen in this group.
- Deletion of 1q36 is present in 80–100% of infantile malignant GCTs in testicular and extragonadal sites.
- Recurrent genetic changes of infantile yolk sac tumors include loss of 6q24-qter, gain of 20q and 1q, loss of 1p, and c-myc or n-myc amplification.
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Cabana, Michael D., editor. "Germ Cell Tumors." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14197/all/Germ_Cell_Tumors.
Germ Cell Tumors. In: Cabana MDM, ed. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14197/all/Germ_Cell_Tumors. Accessed June 5, 2023.
Germ Cell Tumors. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics (7th ed.). Wolters Kluwer Health. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14197/all/Germ_Cell_Tumors
Germ Cell Tumors [Internet]. In: Cabana MDM, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2023 June 05]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14197/all/Germ_Cell_Tumors.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Germ Cell Tumors ID - 14197 ED - Cabana,Michael D, BT - Select 5-Minute Pediatrics Topics UR - https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14197/all/Germ_Cell_Tumors PB - Wolters Kluwer Health ET - 7 DB - Medicine Central DP - Unbound Medicine ER -