Transient Erythroblastopenia of Childhood
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An acquired, self-limited suppression of red cell production in an otherwise healthy child
- Mean age at diagnosis is 26 months.
- <10% are >3 years of age at diagnosis.
- Slight male predominance (male/female 5.1:3.1)
- No seasonal predominance
- There is no simple genetic pattern.
- Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.
There is no known way to prevent transient erythroblastopenia of childhood.
- Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
- A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.
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Cabana, Michael D., editor. "Transient Erythroblastopenia of Childhood." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14179/1.3/Transient_Erythroblastopenia_of_Childhood.
Transient Erythroblastopenia of Childhood. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14179/1.3/Transient_Erythroblastopenia_of_Childhood. Accessed December 5, 2019.
Transient Erythroblastopenia of Childhood. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14179/1.3/Transient_Erythroblastopenia_of_Childhood
Transient Erythroblastopenia of Childhood [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 December 05]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14179/1.3/Transient_Erythroblastopenia_of_Childhood.
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