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- A disorder of the humoral immune system characterized by deficient or absent immunoglobulins and the inability to produce specific antibody
- Subtypes include primary immunodeficiency and secondary deficiency due to other extrinsic disease (i.e., malignancy).
Incidence and prevalence depends on underlying defect or cause. Antibody deficiency syndromes represent ∼70% of primary immune deficiencies.
Genetic defects have been identified in many cases, which are identified in the “Differential Diagnosis.”
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Cabana, Michael D., editor. "Hypogammaglobulinemia." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/1.3.0/Hypogammaglobulinemia.
Hypogammaglobulinemia. In: Cabana MD, ed. Select 5-Minute Pediatrics Topics. 7th ed. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/1.3.0/Hypogammaglobulinemia. Accessed November 21, 2019.
Hypogammaglobulinemia. (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics. Available from https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/1.3.0/Hypogammaglobulinemia
Hypogammaglobulinemia [Internet]. In: Cabana MD, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2019 November 21]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14104/1.3.0/Hypogammaglobulinemia.
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