Bronchopulmonary Dysplasia (BPD)
Basics
DESCRIPTION
- A chronic lung disease (CLD) of premature infants defined as the need for supplemental oxygen for 28 days and a need for supplemental oxygen +/− positive pressure at 36 weeks postmenstrual age (PMA)
- It is categorized as mild, moderate, and severe based on the following at 36 weeks PMA or discharge (whichever comes first).
- Mild: breathing room air
- Moderate: need for <30% oxygen
- Severe: need for >30% oxygen, with or without positive pressure ventilation or continuous positive pressure
EPIDEMIOLOGY
- BPD is the most common CLD in infants.
- Infants with birth weight (BW) <1,250 g account for 97% of all patients with BPD.
- Prevalence based on BW:
- 501 to 750 g: 42%
- 751 to 1,000 g: 25%
- 1,001 to 1,250 g: 11%
- 1,251 to 1,500 g: 5%
RISK-FACTORS
- Infants with gestational age (GA) <28 weeks and BW <1,000 g
- Invasive ventilation
- Exposure to hyperoxia
- Sepsis (in utero and postnatal (PN); local/systemic)
- Genetic predisposition
GENERAL-PREVENTION
- Prevention of premature birth
- Noninvasive ventilation approaches
- Avoidance of hyperoxia
- Decreasing perinatal infections
PATHOPHYSIOLOGY
- Multifactorial with gene–environmental interactions
- Antenatal (AN)—chorioamnionitis
- PN—ventilator injury, hyperoxia, and sepsis
- AN and PN factors act on a genetically predisposed immature lung, causing release of multiple molecular mediators of inflammation, resulting in activation of cellular death pathways, followed by resolution or repair.
- Repair of the injured developing lung results in decreased alveolarization and dysregulated pulmonary vasculature, the pathologic hallmarks of BPD.
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Citation
Cabana, Michael D., editor. "Bronchopulmonary Dysplasia (BPD)." Select 5-Minute Pediatrics Topics, 7th ed., Wolters Kluwer Health, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14051/all/Bronchopulmonary_Dysplasia__BPD_.
Bronchopulmonary Dysplasia (BPD). In: Cabana MDM, ed. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14051/all/Bronchopulmonary_Dysplasia__BPD_. Accessed December 7, 2024.
Bronchopulmonary Dysplasia (BPD). (2015). In Cabana, M. D. (Ed.), Select 5-Minute Pediatrics Topics (7th ed.). Wolters Kluwer Health. https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14051/all/Bronchopulmonary_Dysplasia__BPD_
Bronchopulmonary Dysplasia (BPD) [Internet]. In: Cabana MDM, editors. Select 5-Minute Pediatrics Topics. Wolters Kluwer Health; 2015. [cited 2024 December 07]. Available from: https://im.unboundmedicine.com/medicine/view/Select-5-Minute-Pediatric-Consult/14051/all/Bronchopulmonary_Dysplasia__BPD_.
* Article titles in AMA citation format should be in sentence-case
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T1 - Bronchopulmonary Dysplasia (BPD)
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DB - Medicine Central
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