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Epigastric pain (dyspepsia, upper abdominal pain)


Don’t miss

  • Pancreatitis
  • Cholangitis
  • Myocardial ischemia
  • Pneumonia
  • Abdominal hernia
  • Pregnancy
  • Intestinal ischemia


  • Functional or nonulcer dyspepsia (most common)
  • Peptic ulcer disease
  • Gastroesophageal reflux
  • Gastritis, eg, NSAIDs, alcohol, stress, H. pylori, pernicious anemia
  • Pancreatitis or pancreatic cancer
  • "Indigestion" from overeating, high-fat foods, coffee
  • Other drugs: aspirin, antibiotics (eg, macrolides, metronidazole), corticosteroids, digoxin, narcotics, theophylline
  • Gastroparesis
  • Lactase deficiency
  • Malabsorption
  • Gastric cancer
  • Parasitic infection, eg, Giardia, Strongyloides, Ascaris
  • Cholelithiasis, choledocholithiasis, or cholangitis
  • H. pylori (controversial)
  • Myocardial ischemia or pericarditis
  • Pneumonia
  • Abdominal hernia
  • Pregnancy
  • Intestinal ischemia
  • Esophageal rupture
  • Gastric volvulus
  • Physical or sexual abuse

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Last updated: February 24, 2015


Zeiger, Roni F.. "Epigastric Pain (dyspepsia, Upper Abdominal Pain)." Diagnosaurus, 4th ed., McGraw-Hill Education, 2015. Medicine Central, im.unboundmedicine.com/medicine/view/Diagnosaurus/114440/all/Epigastric_pain__dyspepsia_upper_abdominal_pain_.
Zeiger RF. Epigastric pain (dyspepsia, upper abdominal pain). Diagnosaurus. 4th ed. McGraw-Hill Education; 2015. https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114440/all/Epigastric_pain__dyspepsia_upper_abdominal_pain_. Accessed July 20, 2019.
Zeiger, R. F. (2015). Epigastric pain (dyspepsia, upper abdominal pain). In Diagnosaurus. Available from https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114440/all/Epigastric_pain__dyspepsia_upper_abdominal_pain_
Zeiger RF. Epigastric Pain (dyspepsia, Upper Abdominal Pain) [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2015. [cited 2019 July 20]. Available from: https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114440/all/Epigastric_pain__dyspepsia_upper_abdominal_pain_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Epigastric pain (dyspepsia, upper abdominal pain) ID - 114440 A1 - Zeiger,Roni F, Y1 - 2015/02/24/ BT - Diagnosaurus UR - https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114440/all/Epigastric_pain__dyspepsia_upper_abdominal_pain_ PB - McGraw-Hill Education ET - 4 DB - Medicine Central DP - Unbound Medicine ER -