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Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.


Trade Name(s)

  • herba menthae
  • menta piperita
  • mint

Ther. Class.

Common Uses

  • Abdominal cramps.
  • Dyspepsia.
  • Headache.


Peppermint reduces slow wave frequency in the small intestine, slows peristalsis and directly relaxes gastrointestinal smooth muscle. When applied topically, it has a direct inhibitory effect on sensitized pain receptors and may act centrally to alter pain perception.

Therapeutic Effect(s):

  • Decreased gastrointestinal spasm.
  • Decreased pain sensation.


Absorption: Unknown

Distribution: Unknown

Metabolism and Excretion: Unknown

Half-life: Unknown




Contraindicated in:

  • Hypersensitivity.

Use Cautiously in:

Pregnancy and lactation when using medicinal amounts (above those amounts commonly found in foods).

Adverse Reactions/Side Effects

CNS: headache

Derm: contact dermatitis, flushing

GI: heartburn, nausea, vomiting, stomatitis

Misc: allergic reactions

* CAPITALS indicate life-threatening.
Underline indicate most frequent.


Natural Drug Interaction

  • antacids, H2 antagonists and proton pump inhibitors may cause premature dissolution of enteric-coated peppermint products.
  • May ↑ cyclosporinelevels.




PO: (Adults) Dyspepsia– 1 mL of oil three times daily; Digestive disorders– 0.2–0.4 mL (1–2 enteric-coated capsules) three times daily; Tea– prepare with dried leaves/250 mL boiling water: 3–4 cups daily or 1.5–3 g peppermint oil/150 mL water: 1 cup three times daily.

Topical: (Adults) Headache– 10% peppermint oil in ethanol solution apply to forehead and temples, repeat after 15 and 30 minutes.


Enteric-coated capsules: 0.2 mL oil/capsule

Oil: 10%



  • Assess pain (intensity, location, duration) prior to and periodically during therapy.

Potential Diagnoses

  • Acute pain (Indications)


  • PO: Administer as directed.

Patient/Family Teaching

  • Instruct patient to take peppermint as directed.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Decrease in abdominal pain or dyspepsia.
  • Decrease in headache pain.
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Quiring, Courtney, et al. "Peppermint." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/110142/13/peppermint.
Quiring C, Sanoski CA, Vallerand AH. Peppermint. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/110142/13/peppermint. Accessed June 19, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Peppermint. In Davis's Drug Guide. Available from https://im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/110142/13/peppermint
Quiring C, Sanoski CA, Vallerand AH. Peppermint [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 June 19]. Available from: https://im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/110142/13/peppermint.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - peppermint ID - 110142 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://im.unboundmedicine.com/medicine/view/Davis-Drug-Guide/110142/13/peppermint PB - F.A. Davis Company ET - 16 DB - Medicine Central DP - Unbound Medicine ER -