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Disseminated Superficial Actinic Porokeratosis (DSAP)

Disseminated Superficial Actinic Porokeratosis (DSAP) is a topic covered in the 5-Minute Clinical Consult.

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  • A disorder of keratinization
  • Lesions of the skin with conical papules of a red and brown color surrounding the hair follicle
  • Edges may become raised over time (1).
  • Typically found in 30 to 40 year olds (2)
  • Commonly located on the arms and legs

Etiology and Pathophysiology

Proliferation of atypical keratinocytes from a mutant clonal cell line

  • Genetic studies have revealed mutation of MVK (3).
  • Mutation of keratinocyte proliferation and differentiation (3)
  • Autosomal dominant with variable penetrance (1)

Risk Factors

  • UV-light exposure (2)
  • Male sex (1)
  • Immune suppression (1)
  • Infection (1)

General Prevention

Sunscreen and avoidance of UV exposure (2)

Commonly Associated Conditions

Skin malignancies in up to 10% of people (1)

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Stephens, Mark B., et al., editors. "Disseminated Superficial Actinic Porokeratosis (DSAP)." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis__DSAP_.
Disseminated Superficial Actinic Porokeratosis (DSAP). In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis__DSAP_. Accessed May 22, 2019.
Disseminated Superficial Actinic Porokeratosis (DSAP). (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis__DSAP_
Disseminated Superficial Actinic Porokeratosis (DSAP) [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 May 22]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis__DSAP_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Disseminated Superficial Actinic Porokeratosis (DSAP) ID - 816689 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis__DSAP_ PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -