Disseminated Superficial Actinic Porokeratosis

Disseminated Superficial Actinic Porokeratosis is a topic covered in the 5-Minute Clinical Consult.

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Basics

Description

  • A disorder of keratinization
  • Lesions of the skin with conical papules of a red and brown color surrounding the hair follicle
  • Edges may become raised over time (1).
  • Typically found in 30 to 40 year olds (2)
  • Commonly located on the arms and legs

Etiology and Pathophysiology

Proliferation of atypical keratinocytes from a mutant clonal cell line


Genetics
  • Genetic studies have revealed mutation of MVK (3).
  • Mutation of keratinocyte proliferation and differentiation (3)
  • Autosomal dominant with variable penetrance (1)

Risk Factors

  • UV-light exposure (2)
  • Male sex (1)
  • Immune suppression (1)
  • Infection (1)

General Prevention

Sunscreen and avoidance of UV exposure (2)

Commonly Associated Conditions

Skin malignancies in up to 10% of people (1)

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Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Disseminated Superficial Actinic Porokeratosis ID - 816689 ED - Baldor,Robert A, ED - Domino,Frank J, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816689/all/Disseminated_Superficial_Actinic_Porokeratosis PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -