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Granuloma Faciale

Granuloma Faciale is a topic covered in the 5-Minute Clinical Consult.

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Granuloma faciale (GF) is an uncommon benign and chronic inflammatory skin disease characterized by single/multiple facial cutaneous nodules.


Primarily a disease of middle-aged white men with rare reports of GF in Japanese, blacks, and children

Rare; precise incidence and prevalence are unknown.

Etiology and Pathophysiology

Etiology and pathogenesis are not clearly defined, but several hypotheses exist.

  • Some cases are idiopathic.
  • Production of interleukin-5 by a clonal T-cell population may lead to attraction of eosinophils to the affected area.
  • A γ-interferon–mediated process has also been proposed.
  • Sun exposure may play a role, as lesions are more common in sun-exposed areas and sunlight may darken lesions.

Risk Factors

Sun exposure and heat exposure can darken lesions.

Commonly Associated Conditions

Eosinophilic angiocentric fibrosis (EAF), which involves mucosal lesions of the nose/mouth, may have concurrent GF in approximately 1/4 of cases and should be considered in GF patients with nasal/upper respiratory symptoms.

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Stephens, Mark B., et al., editors. "Granuloma Faciale." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816090/all/Granuloma_Faciale.
Granuloma Faciale. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816090/all/Granuloma_Faciale. Accessed April 24, 2019.
Granuloma Faciale. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816090/all/Granuloma_Faciale
Granuloma Faciale [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 24]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816090/all/Granuloma_Faciale.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Granuloma Faciale ID - 816090 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/816090/all/Granuloma_Faciale PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -