Granuloma Faciale

Granuloma Faciale is a topic covered in the 5-Minute Clinical Consult.

To view the entire topic, please or purchase a subscription.

Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers—anytime, anywhere. Explore these free sample topics:

Medicine Central

-- The first section of this topic is shown below --



Granuloma faciale (GF) is an uncommon benign and chronic inflammatory skin disease characterized by single/multiple facial cutaneous nodules.


Primarily a disease of middle-aged white men with rare reports of GF in Japanese, blacks, and children

Rare; precise incidence and prevalence are unknown.

Etiology and Pathophysiology

Etiology and pathogenesis are not clearly defined, but several hypotheses exist.

  • Some cases are idiopathic.
  • Production of interleukin-5 by a clonal T-cell population may lead to attraction of eosinophils to the affected area.
  • A γ-interferon–mediated process has also been proposed.
  • Sun exposure may play a role, as lesions are more common in sun-exposed areas and sunlight may darken lesions.

Risk Factors

Sun exposure and heat exposure can darken lesions.

Commonly Associated Conditions

Eosinophilic angiocentric fibrosis (EAF), which involves mucosal lesions of the nose/mouth, may have concurrent GF in approximately 1/4 of cases and should be considered in GF patients with nasal/upper respiratory symptoms.

-- To view the remaining sections of this topic, please or purchase a subscription --


* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Granuloma Faciale ID - 816090 ED - Baldor,Robert A, ED - Domino,Frank J, ED - Golding,Jeremy, ED - Stephens,Mark B, BT - 5-Minute Clinical Consult, Updating UR - PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -