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Rumination Syndrome

Rumination Syndrome is a topic covered in the 5-Minute Clinical Consult.

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Basics

Description

  • Functional gastrointestinal disorder characterized by effortless regurgitation of recently ingested food into the mouth. The regurgitated food can be chewed, swallowed, or expectorated (1)[C]. Regurgitation of solids and/or liquids may be repetitive and is usually not associated with nausea or retching.
  • Three patterns of ruminations are reported.
    • Classic/primary rumination—increase in abdominal pressure precedes rumination
    • Secondary rumination—reflux episode precedes the increase in abdominal pressure and subsequent rumination event
    • Supragastric rumination—supragastric belch (caused by inflow of air into esophagus via diaphragmatic contraction) precedes rumination event
  • Diagnosis in adults is based on Rome IV criteria (both criteria must be met; criteria must be fulfilled for the past 3 months with symptom onset at least 6 months prior to diagnosis):
    • (i) Persistent or recurrent regurgitation of recently ingested food into the mouth with subsequent spitting or remastication and swallowing
    • (ii) Regurgitation is not preceded by retching.
      • Supportive criteria:
        • Effortless regurgitation events are usually not preceded by nausea.
        • Regurgitant contains recognizable food that might have a pleasant taste.
        • The process tends to cease when the regurgitated material becomes acidic (1).

Epidemiology

Limited data available on prevalence of rumination syndrome. Estimated prevalence is <1% in general adult population. In patients with eating disorders and fibromyalgia, prevalence is ~7–8% (1).

Etiology and Pathophysiology

  • Pathogenesis of rumination syndrome is unclear. Postprandial regurgitation is thought to occur secondary to coordinated increased intragastric pressures, lower esophageal sphincter (LES) relaxation, and decreased intrathoracic pressures resulting in a pressure gradient between the esophagus and stomach that exceeds the barrier pressure of the LES. Additionally, there may be an additional central reflex mechanism associated with episodes of rumination (1,2)[C].
  • Gastroduodenal manometry has shown “R” (rumination) waves, likely due to an abrupt increase in intra-abdominal pressure associated with rumination episodes; high-resolution esophageal manometry with impedance has shown gastric pressures >30 mm Hg associated with rumination events; abdominal wall electromyography (EMG) shows activation of abdominal wall musculature associated with rumination events.

General Prevention

Pediatric Considerations
Rumination syndrome is associated with dental erosions in children; consider early dental referral for children with rumination syndrome (3)[B].

Commonly Associated Conditions

  • Anorexia nervosa and bulimia nervosa have been reported in up to 20% of patients with rumination syndrome (1).
  • Rectal evacuation disorder has been shown to co-occur with rumination syndrome in adults and adolescents (1).
  • Halitosis was most common initial presenting symptom in those <16 years of age (1).
  • Anxiety
  • Depression

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Citation

Stephens, Mark B., et al., editors. "Rumination Syndrome." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688278/all/Rumination_Syndrome.
Rumination Syndrome. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688278/all/Rumination_Syndrome. Accessed May 22, 2019.
Rumination Syndrome. (2019). In Stephens, M. B., Golding, J., Baldor, R. A., & Domino, F. J. (Eds.), 5-Minute Clinical Consult. Available from https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688278/all/Rumination_Syndrome
Rumination Syndrome [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 May 22]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688278/all/Rumination_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Rumination Syndrome ID - 1688278 ED - Stephens,Mark B, ED - Golding,Jeremy, ED - Baldor,Robert A, ED - Domino,Frank J, BT - 5-Minute Clinical Consult, Updating UR - https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688278/all/Rumination_Syndrome PB - Wolters Kluwer ET - 27 DB - Medicine Central DP - Unbound Medicine ER -